Caspase-3, p53 and Bcl-2 expression in basal cell carcinoma of the eyelid
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TERMEDIA PUBLISHING HOUSE LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Eyelid tumours mostly originated from skin and its appendeges. External carcinogens like UV radiation causes cell damages in the eyelid skin and contributes to carcinogenesis. Apoptosis is a very important mechanism to prevent these damage and probable neoplatic change. Aim: To compare caspase-3, p53 and Bcl-2 levels between patients with basal cell carcinoma (BCC) of the eyelid and healthy individuals. Material and methods: Pathology archives from October 2012 to April 2015 were scanned for BCC biopsies of the eyelid and tissue removed during blepharoplasty and entropion procedures. A total of 36 specimens were found. The specimens were divided into two groups: BCC group and controls (consisting of eyelid tissue removed during routine blepharoplasty). The pathology specimens were then stained using p53, Bcl-2 and caspase-3 stains and the intensity of staining was graded on a 0-3 scale. Results: Samples from a total of 36 patients were included in the study. Eighteen (50.0%) patients were female. There were 13 patients in the BCC group and 23 patients in the control group. The mean age was 66.0 +/- 10.8 years in the BCC group, and 65.61 +/- 11.22 years in the control group. The caspase-3 staining was lower in the BCC group than in the control group. No significant differences were found between the BCC group and the control group in terms of p53 levels or Bcl-2 levels (both of them, p = 1.000). Conclusions: The caspase-3 level was lower in the BCC group. This result suggests that these enzymes can play a significant role in carcinogenesis of eyelid BCC.
Açıklama
Anahtar Kelimeler
basal cell carcinoma, Bcl-2, caspase-3, eyelid tumour, immunohistochemical stain, p53, malignant tumour
Kaynak
POSTEPY DERMATOLOGII I ALERGOLOGII
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
37
Sayı
4
Künye
Koyun, E., Karadag, R., Özkanlı, S. Ş., Oğuztüzün, S., Kocdogan, A. K., & Ozsoy, I. (2020). Caspase-3 p53 and Bcl-2 expression in basal cell carcinoma of the eyelid. Advances in Dermatology and Allergology, 37(4), 535–539.
