The effect of initial periodontal treatment on gingival crevicular fluid galectin-3 levels in participants with periodontal disease

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dc.authoridOlgun, Ebru/0000-0001-7298-8589
dc.contributor.authorKarsiyaka Hendek, M.
dc.contributor.authorOlgun, E.
dc.contributor.authorKisa, U.
dc.date.accessioned2025-01-21T16:45:10Z
dc.date.available2025-01-21T16:45:10Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The aim of study was to evaluate galectin-3 levels in gingival crevicular fluid (GCF) from periodontally healthy (H) patients and those with periodontitis (P), gingivitis (G) and the effect of initial periodontal treatment on GCF galectin-3 level. Methods: A total of 75 participants, 25 patients with periodontitis, 25 with gingivitis and 25 periodontally healthy subjects were included into the study. Patients with periodontal disease received initial periodontal treatment. GCF galectin-3 level was assessed at baseline and at the 6th-8th weeks after completion of periodontal treatment. GCF galectin-3 level was evaluated by enzyme-linked immunosorbent assay. Results: GCF galectin-3 level was the lowest in the H group (102.31[63.07] mu g/30 s), followed by the G group (241.45[145.89] mu g/30 s) and the highest in the P group (338.27[219.37] mu g/30 s). These differences were statistically significant between H and the other groups (P < 0.001). After initial periodontal treatment, GCF galectin-3 level significantly decreased in the G and P groups compared to baseline values (P < 0.01). Conclusion: The results of this study suggest that GCF galectin-3 level is a potential biomarker for the evaluation of gingival inflammation and initial periodontal treatment is effective in decreasing GCF galectin-3 level.
dc.description.sponsorshipScientific Research Project Fund of Kirikkale University [2019/014]
dc.description.sponsorshipThis research was supported by the Scientific Research Project Fund of Kirikkale University under the project number 2019/014.
dc.identifier.doi10.1111/adj.12815
dc.identifier.endpage174
dc.identifier.issn0045-0421
dc.identifier.issn1834-7819
dc.identifier.issue2
dc.identifier.pmid33378559
dc.identifier.scopus2-s2.0-85100168734
dc.identifier.scopusqualityQ2
dc.identifier.startpage169
dc.identifier.urihttps://doi.org/10.1111/adj.12815
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25598
dc.identifier.volume66
dc.identifier.wosWOS:000608491300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAustralian Dental Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectGalectin-3; initial periodontal treatment; periodontal disease
dc.titleThe effect of initial periodontal treatment on gingival crevicular fluid galectin-3 levels in participants with periodontal disease
dc.typeArticle

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