The effects of trastuzumab therapy on endothelial functions of breast cancer patients

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dc.authoridAlp, Caglar/0000-0001-5984-1857
dc.contributor.authorAlp, Caglar
dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorYalcin, Selim
dc.contributor.authorKaral, Ali Oguzhan
dc.date.accessioned2025-01-21T16:45:27Z
dc.date.available2025-01-21T16:45:27Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: Breast cancer is among the highest causes of morbidity and mortality in women. Trastuzumab therapy, which is known to be significantly cardiotoxic, is mainly used to treat patients with resistant breast cancer, including estrogen receptor-positive type. We aimed to show the effects of METHODS: In this study, a total of 26 participants (24 female and 2 male patients, minimum age: 38 years, maximum age: 79 years, and mean age 57.3 +/- 12.7 years) were enrolled in the study. For the statistical evaluation of data, we classified the participants of the study as follows: Pretreatment: Before trastuzumab therapy; Treatment Period 1: 1 month after the first dose of trastuzumab; Treatment Period 2: 4 months after the first dose of trastuzumab; Treatment Period 3: 12 months after the first dose of trastuzumab. We conducted repeated-measures analysis of variance (Greenhouse-Geisser) and paired-sample t-tests to statistically compare the groups using flow-mediated dilation measurements. RESULTS: We determined that there are statistically significant differences between flow-mediated hyperemia and ratio values (flow-mediated dilation) of the groups (p<0.009 and p<0.001, respectively). CONCLUSION: Our data indicate that trastuzumab therapy could have negative effects on endothelial functions in breast cancer patients.
dc.identifier.doi10.1590/1806-9282.20240517
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue9
dc.identifier.pmid39292089
dc.identifier.scopus2-s2.0-85204511974
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20240517
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25649
dc.identifier.volume70
dc.identifier.wosWOS:001317419000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBreast cancer; Trastuzumab; Cardiovascular system; Autonomic nervous system
dc.titleThe effects of trastuzumab therapy on endothelial functions of breast cancer patients
dc.typeArticle

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