Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

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dc.contributor.authorSilventoinen, Karri
dc.contributor.authorJelenkovic, Aline
dc.contributor.authorSund, Reijo
dc.contributor.authorYokoyama, Yoshie
dc.contributor.authorHur, Yoon-Mi
dc.contributor.authorCozen, Wendy
dc.contributor.authorKaprio, Jaakko
dc.date.accessioned2020-06-25T18:22:51Z
dc.date.available2020-06-25T18:22:51Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionMagnusson, Patrik/0000-0002-7315-7899; Christensen, Kaare/0000-0002-5429-5292; Montgomery, Grant W/0000-0002-4140-8139; Fagnani, Corrado/0000-0001-5771-7772; ROMERA, JUAN FRANCISCO SANCHEZ/0000-0002-5405-6216; Siribaddana, Sisira/0000-0001-5821-2557; Tan, Qihua/0000-0003-3194-0030; Busjahn, Andreas/0000-0001-9650-6919; Tan, Qihua/0000-0003-3194-0030; Ordonana, Juan R./0000-0001-7779-6017; Sund, Reijo/0000-0002-6268-8117; Hjelmborg, Jacob/0000-0001-9630-9149; ONCEL, Sevgi YURT/0000-0002-0990-292X; Colodro-Conde, Lucia/0000-0002-9004-364X; Kandler, Christian/0000-0002-9175-235X; McAdams, Tom/0000-0002-6825-3499; mangino, massimo/0000-0002-2167-7470; Huibregtse, Brooke M./0000-0003-0977-7249; Aliev, Fazil/0000-0001-8357-4699; Kaprio, Jaakko/0000-0002-3716-2455; Skytthe, Axel E/0000-0002-8629-4913; Loos, Ruth J F/0000-0002-8532-5087; Pietilainen, Kirsi/0000-0002-8522-1288; Aaltonen, Sari/0000-0002-2873-4263; Pahlen, Shandell/0000-0003-0753-4155; Rasmussen, Finn/0000-0001-7915-7809; van Beijsterveldt, Toos/0000-0002-6617-4201; Franz, Carol/0000-0002-8987-1755; Bartels, Meike/0000-0002-9667-7555; Kyvik, Kirsten Ohm/0000-0003-2981-0245; Willemsen, Gonneke/0000-0003-3755-0236; Pedersen, Nancy/0000-0001-8057-3543; Silventoinen, Karri/0000-0003-1759-3079
dc.description.abstractBackground: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m(2))], but factors modifying these variance components are poorly understood. Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. Design: We used genetic structural equation modeling to analyze BMI in twins >= 20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 2029 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI. Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.en_US
dc.description.sponsorshipMedical Research CouncilMedical Research Council UK (MRC) [G120/635]; NIA NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P30 AG017265, R01 AG018384]; NIDA NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA) [T32 DA017637]; NIDDK NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [P30 DK020541]en_US
dc.identifier.citationSilventoinen, K., Jelenkovic, A., Sund, R., Yokoyama, Y., Hur, Y. M., Cozen, W., Hwang, A. E., Mack, T. M., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Tomizawa, R., Pietilainen, K. H., Rissanen, A., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., ... Kaprio, J. (2017). Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: An individual-based pooled analysis of 40 twin cohorts. American Journal of Clinical Nutrition, 106(2), 457-466.en_US
dc.identifier.doi10.3945/ajcn.117.153643
dc.identifier.endpage466en_US
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.issue2en_US
dc.identifier.pmid28679550
dc.identifier.scopus2-s2.0-85026665173
dc.identifier.scopusqualityQ1
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.3945/ajcn.117.153643
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6930
dc.identifier.volume106en_US
dc.identifier.wosWOS:000406672300007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofAmerican Journal Of Clinical Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBMIen_US
dc.subjectadultsen_US
dc.subjectgeneticsen_US
dc.subjecttwinsen_US
dc.subjectinternational comparisonsen_US
dc.titleDifferences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohortsen_US
dc.typeArticle

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