Association of MEFV mutations and vascular involvement in Behcet's disease: a study from Hatay, Turkey

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dc.contributor.authorSerarslan, Gamze
dc.contributor.authorCura, Sibel Elmacioglu
dc.contributor.authorKimyon, Gezmiş
dc.contributor.authorÜçgül, Gökhan
dc.contributor.authorKaradağ, Mehmet
dc.date.accessioned2025-01-21T16:36:03Z
dc.date.available2025-01-21T16:36:03Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: In this study, we aimed to determine the frequency of MEFV mutations in Behcet's disease (BD) and to investigate the relationship between clinical findings of the disease and the MEFV mutations. Material and methods: A total of 66 participants (30 BD patients, 36 healthy subjects) were included in this study. The MEFV gene was analyzed by using DNA sequence analysis. Results: The distribution of MEFV mutations was not significantly different between the patients and the control group (p = 0.373). However, individuals with R202Q mutation had a risk of OR 4 times (95% CI: 1.1-14.5) higher than those without the mutation (p = 0.035). The rate of vascular involvement was statistically significantly higher in patients with the mutation than in patients without the mutation (p = 0.005). Conclusions: MEFV mutation was associated with vascular involvement in patients with BD. This is also the first study to indicate that the R202Q mutation may have a role in BD. However large series from different regions are required to compare these results.
dc.description.sponsorshipScientific Research Project Fund of Mustafa Kemal University Faculty of Medicine [19]
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Mustafa Kemal University Faculty of Medicine under the project number 19.M.031.
dc.identifier.doi10.5114/reum.2022.117843
dc.identifier.endpage223
dc.identifier.issn0034-6233
dc.identifier.issn2084-9834
dc.identifier.issue3
dc.identifier.pmid35875715
dc.identifier.scopus2-s2.0-85134534191
dc.identifier.scopusqualityQ3
dc.identifier.startpage220
dc.identifier.urihttps://doi.org/10.5114/reum.2022.117843
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24244
dc.identifier.volume60
dc.identifier.wosWOS:000829362800009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofReumatologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectvascular; Behcets disease; MEFV mutation
dc.titleAssociation of MEFV mutations and vascular involvement in Behcet's disease: a study from Hatay, Turkey
dc.typeArticle

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