Effects of ropivacaine on transient-evoked otoacoustic emissions: a rabbit model

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dc.contributor.authorArıkan, Osman Kürşat
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorBudak, Bilgehan
dc.contributor.authorApan, Alparslan
dc.contributor.authorBudak, Gürer
dc.contributor.authorKoç, Can
dc.date.accessioned2020-06-25T17:43:33Z
dc.date.available2020-06-25T17:43:33Z
dc.date.issued2006
dc.description.abstractThe aim of this study was to investigate the effect of ropivacaine, a newer amide local anesthetic, on the ears of rabbits by using transient-evoked otoacoustic emissions (TEOAEs). Thirty rabbits were studied in a random block design of six groups of five animals each. There received intra-tympanically instilled single doses of 0.5 mg/kg, 1.0 mg/kg of ropivacaine, 0.5 ml of isotonic saline (control for intratympanic application), or intravenously administered single doses of 1.0 mg/kg, 2.0 mg/kg of ropivacaine and 1.0 ml of isotonic saline (control for intravenous application). Cochlear function was serially monitored using TEOAEs before administration and on the 1st and 15th days after administrations of ropivacaine or isotonic saline. The responses of TEOAEs were analyzed in terms of mean stimulus, stability, wave reproducibility and emission amplitudes at 1.0-4.0 kHz. We found no significant changes in the TEOAE responses of the baseline measurements in each group before administration and the responses at each interval in the same group after administration throughout the experiment (P > 0.05). Also, no significant difference was found between the group receiving ropivacaine administered intravenously or intratympanicly and the control group at each interval (P > 0.05). The data from the present study showed that ropivacaine, whether administered intravenously or intratympanically and even at a low or high dose, has no effects on the responses of TEOAEs in the early period. These findings encourage the use of ropivacaine as a safe agent without ototoxic effects in peripheral nerve blocks, epidural and intravenous regional anesthesia or even tinnitus therapy in the future.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00405-005-1029-8
dc.identifier.endpage425en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue5en_US
dc.identifier.pmid16408239
dc.identifier.scopus2-s2.0-33744503692
dc.identifier.scopusqualityQ1
dc.identifier.startpage421en_US
dc.identifier.urihttps://doi.org10.1007/s00405-005-1029-8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3793
dc.identifier.volume263en_US
dc.identifier.wosWOS:000237793400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectropivacaineen_US
dc.subjecttransient-evoked otoacoustic emissionen_US
dc.subjectrabbiten_US
dc.titleEffects of ropivacaine on transient-evoked otoacoustic emissions: a rabbit modelen_US
dc.typeArticle

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