Increased seropositivity of Helicobacter pylori cytotoxin-associated gene-A in Behcet's disease

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dc.contributor.authorApan, Teoman Zafer
dc.contributor.authorGürsel, Ragip
dc.contributor.authorDolgun, Alp
dc.date.accessioned2020-06-25T17:43:46Z
dc.date.available2020-06-25T17:43:46Z
dc.date.issued2007
dc.description.abstractBehcet's disease is a systemic vasculitic syndrome with unknown etiology. The aim of the present study was to compare the Helicobacter pylori seropositivity and cytotoxin associated gene-A status in patients with Behcet's disease. Ninety-one patients with Behcet's disease and 83 age- and sex-matched persons with or without any gastrointestinal complaints were included in the study. Demographic characteristics and H. pylori IgG, IgM, and cytotoxin-associated gene-A IgG status of the Behcet's disease and the control groups were analyzed. The influence of eradication therapy on clinical findings was also determined. The prevalence of H. pylori IgG seropositivity was slightly but not significantly higher in patients with Behcet's disease compared to the controls [72 (79.1%) vs 56 (67.5%), (p=0.082)]. The prevalence of cytotoxin-associated gene A positivity was significantly higher in Behcet's disease compared to the controls [59 (64.8.%) vs 32 (38.5%), respectively, (p=0.002)]. Eradication of H. pylori has significantly decreased clinical manifestations such as oral and genital ulceration, arthritis/arthralgia, and cutaneous findings of Bahcet's disease. Our study indicates that H. pylori may be involved in the pathogenesis of Behcet's disease or disease activity might be enhanced due to induced inflammation or altered immunity.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s10067-006-0416-x
dc.identifier.endpage889en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue6en_US
dc.identifier.pmid17021670
dc.identifier.scopus2-s2.0-34250789364
dc.identifier.scopusqualityQ1
dc.identifier.startpage885en_US
dc.identifier.urihttps://doi.org10.1007/s10067-006-0416-x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3884
dc.identifier.volume26en_US
dc.identifier.wosWOS:000246178800007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectcytotoxin associated gene-Aen_US
dc.subjectELISAen_US
dc.subjectHelicobacter pylorien_US
dc.titleIncreased seropositivity of Helicobacter pylori cytotoxin-associated gene-A in Behcet's diseaseen_US
dc.typeArticle

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