Identification of the concentration of iodopovidone pleurodesis in rats for the maximal effectiveness

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dc.contributor.authorYazkan, Rasih
dc.contributor.authorOzpolat, Berkant
dc.contributor.authorDuman, Levent
dc.contributor.authorBircan, Sema
dc.contributor.authorBozkurt, Kemal Kursat
dc.contributor.authorGunes, Sedat
dc.date.accessioned2020-06-25T18:07:10Z
dc.date.available2020-06-25T18:07:10Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionOzpolat, Berkant/0000-0002-6203-7306
dc.description.abstractBackground: This study aims to investigate the efficacy and safety of different doses of iodopovidone for pleurodesis and to evaluate the histopathological changes in thyroid tissue. Methods: Thirty-eight male Albino Wistar rats (260-320 g, 6-8 months old) included in this experimental study were randomly divided into four groups. Groups 1, 2, and 3 were given 2 mL/kg intrapleural iodopovidone at concentrations of 1%, 2%, 4%, respectively, while group 4 was administered intrapleural saline. The surfaces were graded by macroscopic and microscopic examination on Day 30 and thyroid tissues were histopathologically examined. Results: Iodopovidone at concentrations of 2% and 4% resulted in significantly more adhesions and inflammatory response. Four percent iodopovidone produced nonsignificant microscopic changes in the contralateral visceral pleural surface. No vacuolization in thyroid tissue showing hyperthyroidism was observed in the groups. Conclusion: We suggest that 2% iodopovidone is enough for an effective and safe pleurodesis and the concentration of iodopovidone may be raised to 4% in unsuccessful cases. However, as the study was conducted on rats, it still remains to be elucidated that the similar results can be achieved in human studies.en_US
dc.identifier.citationYazkan R., Özpolat B., Duman L., Bircan S., Bozkurt K. K., Güneş S. (2013). Identification of the concentration of iodopovidone pleurodesis in rats for the maximal effectiveness. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 21(3), 737 - 742.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2013.7696
dc.identifier.endpage742en_US
dc.identifier.issn1301-5680
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84880709294
dc.identifier.scopusqualityQ3
dc.identifier.startpage737en_US
dc.identifier.trdizinid159766
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2013.7696
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5499
dc.identifier.volume21en_US
dc.identifier.wosWOS:000321798900027
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIodineen_US
dc.subjectiodopovidoneen_US
dc.subjectpleurodesisen_US
dc.subjectthyroiden_US
dc.titleIdentification of the concentration of iodopovidone pleurodesis in rats for the maximal effectivenessen_US
dc.typeArticle

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