Paracetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativa

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dc.contributor.authorCanayakin, Dogukan
dc.contributor.authorBayir, Yasin
dc.contributor.authorBaygutalp, Nurcan Kilic
dc.contributor.authorKaraoglan, Esen Sezen
dc.contributor.authorAtmaca, Hasan Tarik
dc.contributor.authorOzgeris, Fatma Betul Kocak
dc.contributor.authorHalici, Zekai
dc.date.accessioned2020-06-25T18:17:08Z
dc.date.available2020-06-25T18:17:08Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionbayir, yasin/0000-0003-3562-6727; ATMACA, HASAN TARIK/0000-0001-8379-4114
dc.description.abstractContext Nigella sativa L. (Ranunculaceae) (NS) is traditionally used to treat many conditions such as inflammation. Objective This study evaluates the effects of NS seeds ethanol extract in paracetamol-induced acute nephrotoxicity in rats. Materials and methods Forty-eight female Wistar Albino rats were divided into eight groups: I = sham; II = sham + 1000 mg/kg NS; III = sham + 140 mg/kg (N-acetyl cysteine) NAC; IV = 2 g/kg paracetamol; V = 2 g/kg paracetamol + 140 mg/kg NAC; VI, VII and VIII = 2 g/kg paracetamol + 250, 500 and 1000 mg/kg NS, respectively. Paracetamol administration (oral) was carried out 1 h after NS and NAC administrations (oral), and all animals were sacrificed 24 h later. Results Paracetamol administration significantly increased serum urea (88.05 U/L) and creatinine (0.80 U/L) when compared with the sham group (49.80 and 0.31 U/L, respectively). However, serum urea level was reduced to 65.60, 56.00 and 54.18 U/L, with 250, 500 and 1000 mg/kg doses of the extract, respectively. Also, serum creatinine level was reduced to 0.64, 0.57 and 0.52 U/L with 250, 500 and 1000 mg/kg doses of the extract, respectively. NS administration increased superoxide dismutase and glutathione, and decreased malondialdehyde levels in the kidneys. Kidney histopathological examinations showed that NS administration antagonized paracetamol-induced kidney pathological damage. Discussion and conclusions The results suggest NS has a significant nephroprotective activity on paracetamol-induced nephrotoxicity. It may be suggested that the antiinflammatory and antioxidant effects of NS ethanolic extract originated from different compounds of its black seeds.en_US
dc.description.sponsorshipResearch fund of Ataturk UniversityAtaturk University [BAP-2012/077]en_US
dc.description.sponsorshipThis study was supported by the Research fund of Ataturk University (BAP-2012/077).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/13880209.2016.1145701
dc.identifier.endpage2091en_US
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue10en_US
dc.identifier.pmid26956915
dc.identifier.scopus2-s2.0-84986292227
dc.identifier.scopusqualityQ1
dc.identifier.startpage2082en_US
dc.identifier.urihttps://doi.org/10.3109/13880209.2016.1145701
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6704
dc.identifier.volume54en_US
dc.identifier.wosWOS:000386041500016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlutathioneen_US
dc.subjectkidneyen_US
dc.subjectmalondialdehydeen_US
dc.subjectsuperoxide dismutaseen_US
dc.titleParacetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativaen_US
dc.typeArticle

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