Is Gastric Xanthelasma an Alarming Endoscopic Marker for Advanced Atrophic Gastritis and Intestinal Metaplasia?

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dc.contributor.authorKoksal, Aydin Seref
dc.contributor.authorSuna, Nuretdin
dc.contributor.authorKalkan, Ismail Hakki
dc.contributor.authorEminler, Ahmet Tarik
dc.contributor.authorSakaogullari, Sukran Ziysan
dc.contributor.authorTurhan, Nesrin
dc.contributor.authorParlak, Erkan
dc.date.accessioned2020-06-25T18:16:10Z
dc.date.available2020-06-25T18:16:10Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe clinical significance of gastric xanthelasmas is unknown. We conducted a case-control study in order to evaluate whether gastric xanthelasma is an indicator of advanced atrophic gastritis and intestinal metaplasia. The study was conducted among 1400 patients who underwent elective upper endoscopy. Patients with gastric xanthelasma and atrophy and/or intestinal metaplasia constituted the study group (n = 55). The control group involved patients with only atrophic gastritis and/or intestinal metaplasia (n = 50). Histopathologic findings of the groups including the distribution of atrophic gastritis and/or intestinal metaplasia, operative link on gastritis assessment score, operative link on gastritis intestinal metaplasia assessment (OLGIM) score, and presence of dysplasia and malignancy were compared. Subgroup analysis was performed in order to establish the relation between the characteristics (size, number, and localization) of xanthelasmas, atrophy, and intestinal metaplasia. Multifocal atrophic gastritis was significantly more common in patients with a gastric xanthelasma (41.8 vs. 26.0 %, p = 0.03). Patients with multiple xanthelasmas had a significantly higher rate of intestinal metaplasia (p = 0.02) and a higher OLGIM score (p = 0.02) compared to those with a single xanthelasma. Dysplasia was detected in 8 (14.5 %) patients with a xanthelasma and 4 (8.0 %) patients without a xanthelasma (p = 0.2). Gastric xanthelasma(s) is a warning endoscopic sign for the presence of multifocal atrophic gastritis and advanced intestinal metaplasia.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s10620-016-4210-6
dc.identifier.endpage2955en_US
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.issue10en_US
dc.identifier.pmid27250981
dc.identifier.scopus2-s2.0-84973165176
dc.identifier.scopusqualityQ1
dc.identifier.startpage2949en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-016-4210-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6443
dc.identifier.volume61en_US
dc.identifier.wosWOS:000384211900024
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases And Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectXanthelasmaen_US
dc.subjectAtrophyen_US
dc.subjectMetaplasiaen_US
dc.subjectOperative link on gastritis assessmenten_US
dc.subjectOperative link on gastritis intestinal metaplasia assessmenten_US
dc.titleIs Gastric Xanthelasma an Alarming Endoscopic Marker for Advanced Atrophic Gastritis and Intestinal Metaplasia?en_US
dc.typeArticle

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