Histological and biomechanical effects of zoledronate on fracture healing in an osteoporotic rat tibia model

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dc.contributor.authorTurker, Mehmet
dc.contributor.authorAslan, Arif
dc.contributor.authorCirpar, Meric
dc.contributor.authorKochai, Alauddin
dc.contributor.authorTulmac, Ozlem Banu
dc.contributor.authorBalci, Mahi
dc.date.accessioned2020-06-25T18:22:27Z
dc.date.available2020-06-25T18:22:27Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: This study aims to investigate the effects of zoledronate therapy on histological and biomechanical properties of bone healing via a fracture model generated on osteoporotic rat tibiae. Materials and methods: Ovariectomized 40 Wistar-Dawley female rats weighing 300 g to 350 g were used in the study. After one week, 2 IU/g heparin injection was started subcutaneously. After four weeks of daily injections, osteoporosis was ensued proven with bone mineral density measurements. Osteoporotic rats were separated into four equal groups randomly as group A (control), group B (calcium and vitamin D), group C (0.1 mg/kg subcutaneous zoledronic acid), and group D (calcium and vitamin D / 0.1 mg/kg subcutaneous zoledronic acid). Six weeks later, all rats were sacrificed, their tibiae were resected, and histopathologic and biomechanical studies were performed. Results: Group C (30.2 +/- 1 Nm) and group D (33.3 +/- 3 Nm) had significantly higher peak torque values than group A (21.6 +/- 6 Nm) and group B (23.6 +/- 4 Nm) (p=0.007 and p=0.005, respectively). Group C (1.8) and group D (2.0) had higher stiffness values than group A (1.4) and group B (1.7); however, the difference was not statistically significant (p>0.05 for all). Conclusion: According to histopathological and biomechanical test results, single dose zoledronic acid treatment improves fracture healing in an osteoporotic rat fracture model. Orally administered daily calcium and vitamin D treatment had no effect on fracture healing. There was no additional improvement in fracture healing when calcium and vitamin D treatment was added to zoledronic acid treatment. Positive effects of zoledronic acid treatment on osteoporotic fracture healing and callus quality should be shown by future clinical studies.en_US
dc.description.sponsorshipKirikkale University Scientific Research ProjectKirikkale Universityen_US
dc.description.sponsorshipThe authors declare that this study was funded by Kirikkale University Scientific Research Project.en_US
dc.identifier.citationTürker, M., Aslan, A., Çırpar, M., Kochai, A., Tulmaç, Ö. B., & Balcı, M. (2016). Histological and biomechanical effects of zoledronate on fracture healing in an osteoporotic rat tibia model. Eklem hastaliklari ve cerrahisi = Joint diseases & related surgery, 27(1), 9–15.en_US
dc.identifier.doi10.5606/ehc.2016.03
dc.identifier.endpage15en_US
dc.identifier.issn1305-8282
dc.identifier.issn1309-0313
dc.identifier.issue1en_US
dc.identifier.pmid26874629
dc.identifier.scopus2-s2.0-84958149309
dc.identifier.scopusqualityN/A
dc.identifier.startpage9en_US
dc.identifier.trdizinid261325
dc.identifier.urihttps://doi.org/10.5606/ehc.2016.03
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6739
dc.identifier.volume27en_US
dc.identifier.wosWOS:000376377700003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofEklem Hastaliklari Ve Cerrahisi-Joint Diseases And Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone healingen_US
dc.subjectosteoporosisen_US
dc.subjectzoledronic aciden_US
dc.titleHistological and biomechanical effects of zoledronate on fracture healing in an osteoporotic rat tibia modelen_US
dc.typeArticle

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