Histopathologic investigation of the effects of prostaglandin E2 administered by different methods on tooth movement and bone metabolism

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dc.contributor.authorCaglaroglu, Murat
dc.contributor.authorErdem, Abdulvahit
dc.date.accessioned2020-06-25T18:06:34Z
dc.date.available2020-06-25T18:06:34Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionErdem, Abdulvahit/0000-0002-6151-3470
dc.description.abstractObjective: The aim of this study was to investigate and compare the in vivo effects of prostaglandin E2 (PGE2) administered by different methods on orthodontic tooth movement and bone metabolism macroscopically, histopatologically, and biochemically. Methods: Forty-five young adult New Zealand rabbits were randomly divided into 3 experimental groups (n = 10/group), 1 positive control group (n = 10), and 1 negative control group (n = 5). The experimental rabbits were fitted with springs exerting 20-g reciprocal force on the maxillary incisors and PGE2 (10 mu g/mL) was administered by the intravenous, submucosal, or intraligamentous route after appliance insertion and on days 1, 3, 7, and 14 thereafter. All rabbits were sacrificed on day 21 and their premaxillae were resected for histologic evaluation. Results: Tooth movement was observed in the experimental and positive control groups, but the intraligamentous PGE2 group had the highest values of all analyzed parameters, including serum calcium and phosphorus levels and osteoclastic and osteoblastic populations (p < 0.001). Conclusions: Submucosal and intraligamentous PGE2 administration significantly increases orthodontic tooth movement and bone metabolism, but the intraligamentous route seems to be more effective. [Korean J Orthod 2012;42(3):118-128]en_US
dc.description.sponsorshipAtaturk University, TurkeyAtaturk Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Fund of Ataturk University, Turkey.en_US
dc.identifier.citationCağlaroğlu, M., & Erdem, A. (2012). Histopathologic investigation of the effects of prostaglandin E2 administered by different methods on tooth movement and bone metabolism. Korean journal of orthodontics, 42(3), 118–128.en_US
dc.identifier.doi10.4041/kjod.2012.42.3.118
dc.identifier.endpage128en_US
dc.identifier.issn2234-7518
dc.identifier.issue3en_US
dc.identifier.pmid23112942
dc.identifier.scopus2-s2.0-84863827166
dc.identifier.scopusqualityQ1
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.4041/kjod.2012.42.3.118
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5253
dc.identifier.volume42en_US
dc.identifier.wosWOS:000306050500004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Assoc Orthodontistsen_US
dc.relation.ispartofKorean Journal Of Orthodontics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPGE2en_US
dc.subjectExperimental tooth movementen_US
dc.subjectIntraligamentaryen_US
dc.subjectOptical dissector methoden_US
dc.titleHistopathologic investigation of the effects of prostaglandin E2 administered by different methods on tooth movement and bone metabolismen_US
dc.typeArticle

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