Cotinine levels in serum and bronchoalveolar lavage fluid

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dc.contributor.authorDiken, Özlem Ercen
dc.contributor.authorUnculu, Serap
dc.contributor.authorKarnak, Demet
dc.contributor.authorÇağlayan, Osman
dc.contributor.authorGöçmen, Jülide Sedef
dc.contributor.authorKayacan, Oya
dc.date.accessioned2020-06-25T17:49:19Z
dc.date.available2020-06-25T17:49:19Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionKarnak, Demet/0000-0001-8463-9802; Kayacan, Oya/0000-0001-5842-4226
dc.description.abstractCotinine is a major metabolite of nicotine. This study was planned to investigate the relationship between bronchoalveolar lavage (BAL) fluid cotinine levels and serum cotinine levels in smokers and nonsmokers with various pulmonary diseases and to investigate whether these levels are affected by passive smoking. Serum and BAL fluid cotinine levels were measured in 27 patients. BAL cotinine levels were measured using a sensitive ELISA kit produced to measure cotinine in saliva. Plates were read by mu Quant (BioTek, USA) micro plate reader. All patient serum cotinine levels were detectable except for one nonsmoker patient. However, BAL fluid cotinine levels were measurable in only 6 patients (two of them were nonsmokers). A significant positive correlation was seen between serum and BAL fluid cotinine levels (r=0.726; p=0.000). Serum cotinine levels were significantly higher in present smokers than non-smokers (21.0 +/- 16.01; 5.35 +/- 7.65;p=0.004). However, there were no significant differences in BAL fluid cotinine levels between smokers and nonsmokers. Passive smoking can increase nicotine metabolites in serum and other body fluids, including BAL fluid. Since BAL fluid and serum cotinine levels were well correlated, there is no need to use invasive procedures, such as bronchoscopy and expensive, time consuming BAL fluid analyses. Serum cotinine levels can give a rough idea of smoking status. BAL fluid cotinine meaurements should be done for only scientific reasons.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage1257en_US
dc.identifier.issn0125-1562
dc.identifier.issue5en_US
dc.identifier.pmid21073047
dc.identifier.scopus2-s2.0-79952113530
dc.identifier.scopusqualityQ4
dc.identifier.startpage1252en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4692
dc.identifier.volume41en_US
dc.identifier.wosWOS:000283401500026
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoutheast Asian Ministers Educ Organizationen_US
dc.relation.ispartofSoutheast Asian Journal Of Tropical Medicine And Public Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcotinineen_US
dc.subjectnicotineen_US
dc.subjectbronchoalveolar lavage fluiden_US
dc.titleCotinine levels in serum and bronchoalveolar lavage fluiden_US
dc.typeArticle

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