Intravaginal application of misoprostol improves pregnancy termination with cabergoline and alfaprostol in dogs

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dc.contributor.authorÇetin, Yunus
dc.contributor.authorMacun, Hasan C.
dc.contributor.authorBeceriklisoy, Hakki B.
dc.contributor.authorSchaefer-Somi, Sabine
dc.contributor.authorAslan, Selim
dc.date.accessioned2020-06-25T17:51:14Z
dc.date.available2020-06-25T17:51:14Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionCetin, Yunus/0000-0002-5402-9429
dc.description.abstractThe goal of this study was to compare three different medications for the induction of abortion in bitches between day 22 and 40 after mismating, to reduce the dosage and frequency of PGF(2 alpha) applications and to investigate the effects of additional intravaginal applications of misoprostol, a PGE(1) analog. For this purpose, 22 bitches of different breeds were assigned to three groups: group 1 (n = 6) received cabergoline (Galastop (R), 10 mu g/kg daily, po) until abortion was complete (first application= day 0) and one administration of alfaprostol (Gabbrostim (R), 10 mu g/kg at day 3, s. c.); group 2 (n = 9) was administered cabergoline (10 mu g/kg daily, po) and alfaprostol (10 mu g/kg at days 0 and 3, s. c.); and group 3 (n = 7) received the same combination as group 2 in addition to misoprostol (Cytotec (R), 400 mu g for bitches with <= 20 kg bw, 600 mu g for bitches with >20 kg bw, every other day, intravaginally). Abortion occurred in 83.3%, 77.7% and 100% of cases in group 1, 2 and 3, respectively (p > 0.05). Cervical dilatation time was shortest in group 3 (3.1 +/- 0.9 days vs. group 1: 5.4 +/- 2.8 and group 2: 5.5 +/- 2.5; p < 0.05). Minor side effects like transient anorexia, weakness, mild vomiting and diarrhea or low grade hair loss were found in 30.3%, 54.3% and 54.0% of cases in group 1, 2 and 3, respectively. We conclude that a combination of oral cabergoline (10 mu g/kg) and alfaprostol (10 mu g/kg) is an effective method for inducing termination of pregnancy in bitches, However, a combination of oral cabergoline (10 mu g/kg), alfaprostol (10 mu g/kg) and administration of additional intravaginal misoprostol may be even more effective.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.2376/0005-9366-123-236
dc.identifier.endpage242en_US
dc.identifier.issn0005-9366
dc.identifier.issn1439-0299
dc.identifier.issue5-6en_US
dc.identifier.pmid20496831
dc.identifier.scopus2-s2.0-77954611975
dc.identifier.scopusqualityQ3
dc.identifier.startpage236en_US
dc.identifier.urihttps://doi.org/10.2376/0005-9366-123-236
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4748
dc.identifier.volume123en_US
dc.identifier.wosWOS:000277684300010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSchluetersche Verlagsgesellschaft Mbh & Co Kgen_US
dc.relation.ispartofBerliner Und Munchener Tierarztliche Wochenschrift
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectabortion inductionen_US
dc.subjectalfaprostolen_US
dc.subjectbitchen_US
dc.subjectcabergolineen_US
dc.subjectmisoprostolen_US
dc.titleIntravaginal application of misoprostol improves pregnancy termination with cabergoline and alfaprostol in dogsen_US
dc.typeArticle

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