Quantative computerized tomography assessment of lung density as a predictor of postoperative pulmonary morbidity in patients with lung cancer

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dc.contributor.authorKaplan, Tevfik
dc.contributor.authorAtac, Gokce Kaan
dc.contributor.authorGunal, Nesimi
dc.contributor.authorKocer, Bulent
dc.contributor.authorAlhan, Aslihan
dc.contributor.authorCubuk, Sezai
dc.contributor.authorHan, Serdar
dc.date.accessioned2020-06-25T18:13:02Z
dc.date.available2020-06-25T18:13:02Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionCubuk, Sezai/0000-0003-4277-6360
dc.description.abstractBackground: The aim of this study was to evaluate the pulmonary reserve of the patients via preoperative quantitative computerized tomography (CT) and to determine if these preoperative quantitative measurements could predict the postoperative pulmonary morbidity. Methods: Fifty patients with lung cancer who underwent lobectomy/segmentectomy were included in the study. Preoperative quantitative CT scans and pulmonary function tests data were evaluated retrospectively. We compare these measurements with postoperative morbidity. Results: There were 32 males and 18 females with a mean age of 54.4 +/- 13.9 years. Mean total density was -790.6 +/- 73.4 HU. The volume of emphysematous lung was (<-900 HU) 885.2 +/- 1,378.4 cm(3). Forced expiratory volume in one second (FEV1) (r=-0.494, P=0.02) and diffusion capacity of carbon monoxide (DLCO) (r=-0.643, P<0.001) were found to be correlate with the volume of emphysematous lung. Furthermore FEV1 (r=0.59, P<0.001) and DLCO (r=0.48, P<0.001) were also found to be correlate with mean lung density. Postoperative pulmonary morbidity was significantly higher in patients with lower lung density (P<0.001), larger volume of emphysema (P<0.001) and lower DLCO (P=0.039). A cut-off point of -787.5 HU for lung density showed 86.96% sensitivity and 81.48% specificity for predicting the pulmonary morbidity (kappa =-0.68, P<0.001). Additionally a cut-off point of 5.41% for emphysematous volume showed 84.00% sensitivity and 80.00% specificity for predicting the pulmonary morbidity (kappa = 0.64, P<0.001). According to logistic regression analyses emphysematous volume > 5.41% (P=0.014) and lung density <-787.5 HU (P=0.009) were independent prognostic factors associated with postoperative pulmonary morbidity. Conclusions: In this study, the patients with a lower lung density than -787.5 HU and a higher volume of emphysema than 5.41% were found to be at increased risk for developing postoperative pulmonary morbidity. More stringent precautions should be taken in those patients that were found to be at high risk to avoid pulmonary complications.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3978/j.issn.2072-1439.2015.07.26
dc.identifier.endpage1397en_US
dc.identifier.issn2072-1439
dc.identifier.issn2077-6624
dc.identifier.issue8en_US
dc.identifier.pmid26380765
dc.identifier.scopus2-s2.0-84940484923
dc.identifier.scopusqualityQ2
dc.identifier.startpage1391en_US
dc.identifier.urihttps://doi.org/10.3978/j.issn.2072-1439.2015.07.26
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6106
dc.identifier.volume7en_US
dc.identifier.wosWOS:000362069800031
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAme Publ Coen_US
dc.relation.ispartofJournal Of Thoracic Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreoperative careen_US
dc.subjectsurgeryen_US
dc.subjectcomplicationsen_US
dc.subjectlung cancer surgeryen_US
dc.subjectemphysemaen_US
dc.titleQuantative computerized tomography assessment of lung density as a predictor of postoperative pulmonary morbidity in patients with lung canceren_US
dc.typeArticle

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