The role of oxidative stress in onychomycosis: Thiol/disulphide homeostasis

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dc.authoridMETIN, Mahmut Sami/0000-0002-5099-8521
dc.contributor.authorMetin, Mahmut Sami
dc.contributor.authorElmas, Omer Faruk
dc.contributor.authorDemirbas, Abdullah
dc.contributor.authorErel, Ozcan
dc.contributor.authorAtasoy, Mustafa
dc.contributor.authorTursen, Umit
dc.contributor.authorLotti, Torello
dc.date.accessioned2025-01-21T16:55:18Z
dc.date.available2025-01-21T16:55:18Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives Onychomycosis is the general term to define fungal nail infections that arise from dermatophytes, non-dermatophytic moulds and yeasts. Thiol/disulphide homeostasis is a new indicator of oxidative stress. In this study, we aimed to investigate the role of thiol/disulphide balance in the pathogenesis of onychomycosis. Methods This cross-sectional study included adult patients with onychomycosis who were admitted to the dermatology department and healthy adult volunteers without any dermatologic or systemic condition. The patients and controls were evaluated in terms of native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios. The possible association between these parameters and clinical subtypes of onychomycosis and demographic characteristics was also investigated. Results A total of 52 patients with onychomycosis and 50 healthy subjects were enrolled in the study. The patient group showed lower levels of total thiol, native thiol and native thiol/total thiol ratio, and higher ratios of disulphide/native thiol and disulphide/total thiol. No statistically significant relationship was found between the parameters, clinical subtypes of onychomycosis and demographic characteristics (p > .05). Conclusion Patients with onychomycosis showed a shifted thiol/disulphide homeostasis towards oxidative stress with a reduction in thiols and an increase in disulphide/native thiol, and disulphide/total thiol ratios. These findings may indicate the role of oxidative stress in the pathogenesis of onychomycosis.
dc.identifier.doi10.1111/myc.13299
dc.identifier.endpage953
dc.identifier.issn0933-7407
dc.identifier.issn1439-0507
dc.identifier.issue8
dc.identifier.pmid33964024
dc.identifier.scopus2-s2.0-85106321050
dc.identifier.scopusqualityQ1
dc.identifier.startpage947
dc.identifier.urihttps://doi.org/10.1111/myc.13299
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25756
dc.identifier.volume64
dc.identifier.wosWOS:000653241500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMycoses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectdermatophytes; fungal infections; pathogenesis
dc.titleThe role of oxidative stress in onychomycosis: Thiol/disulphide homeostasis
dc.typeArticle

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