The role of endothelial nitric oxide synthase (eNOS) in the pathogenesis of sinonasal polyps

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dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorArıkan, Osman K.
dc.contributor.authorAtasoy, Pınar
dc.contributor.authorKılıç, Rahmi
dc.contributor.authorYalçınozan, E. Tuna
dc.date.accessioned2020-06-25T18:12:16Z
dc.date.available2020-06-25T18:12:16Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: The pathogenesis of sinonasal polyps has not been known completely. We investigated the role of endothelial Nitric Oxide Synthase (eNOS) in the pathogenesis of sinonasal polyps. PATIENTS AND METHODS: Study group (Groups 1-3) consisted of nasal polyp samples of patients with sinonasal polyps; and control group consisted of inferior turbinate samples of patients without nasal polyp. In Group 1: 14 specimens from ethmoid sinus; in Group 2: 10 specimens from nasal cavity; in Group 3: 10 specimens from maxillary sinus; and in Group 4 (Control): 9 specimens from inferior turbinate were included. By immunohistochemical staining technique, eNOS Positivity Index in mucosal layers; and in the inflammatory cells were assessed. RESULTS: eNOS Positivity Index was higher at apical layer of epithelium; and perivascular and glandular parts of subepithelial layer. As a rate of mononuclear cells increased, eNOS positivity increased at basal part of epithelium. In eNOS Positivity Index of mononuclear cells increased ones, eNOS values also increased at glands of subepithelial layer. In nasal cavity, eNOS positivity index of all cells was significantly higher than that of the control group. Increased eNOS all cells positivity index values were seen with decreased glandular and endothelial eNOS values. In all cells group, fibroblasts were seen beside the mononuclear cells. It was observed that eNOS was not expressed in PMNC (mainly neutrophils), growing more in acute inflammatory process; and was expressed in MNCs and all cells group with fibroblasts which were the cells of chronic inflammatory process. Especially MNCs and fibroblasts may play a role in the polyp formation process. In males and in patients with longer polyp duration, eNOS values decreased. CONCLUSIONS: We concluded that eNOS Positivity Index was higher at apical layer of epithelium; and perivascular and glandular parts of subepithelial layer. eNOS plays role in vascular dilatation, increases in vascular permeability; increases in nasal secretion due to glandular secretion; and edema in subepithelial and deep layers of the mucosa by affecting glands. Irritant agents in the breathing air and environment may cause increase in eNOS values at apical part of epithelium and may promote polyp formation by vasodilatation and increased glandular secretion due to increased nitric oxide values. In elderly patients and in long standing polyps, eNOS values decreased causing more fibrotic polyps.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage929en_US
dc.identifier.issn1128-3602
dc.identifier.issue6en_US
dc.identifier.pmid24706320
dc.identifier.scopus2-s2.0-84902089629
dc.identifier.scopusqualityQ2
dc.identifier.startpage918en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5838
dc.identifier.volume18en_US
dc.identifier.wosWOS:000341968400024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSinonasal polypen_US
dc.subjectPathogenesisen_US
dc.subjectEndothelial nitric oxide synthase (eNOS)en_US
dc.subjectEndothelialen_US
dc.subjectGlandularen_US
dc.subjecteNOS positivity indexen_US
dc.titleThe role of endothelial nitric oxide synthase (eNOS) in the pathogenesis of sinonasal polypsen_US
dc.typeArticle

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