Serum levels of nitrate, nitrite and advanced oxidation protein products (AOPP) in patients with nonalcoholic fatty liver disease

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dc.contributor.authorCiftci, Aydin
dc.contributor.authorYilmaz, Bulent
dc.contributor.authorKoklu, Seyfettin
dc.contributor.authorYuksel, Osman
dc.contributor.authorOzsoy, Metin
dc.contributor.authorErden, Gonul
dc.contributor.authorCesur, Salih
dc.date.accessioned2020-06-25T18:13:20Z
dc.date.available2020-06-25T18:13:20Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and study aims : Oxidative stress is increased and anti-oxidant defense mechanisms are impaired in patients with hepatosteatosis. The aim of the present study was to evaluate the serum levels of several oxidant and anti-oxidant markers in patients with nonalcoholic fatty liver disease (NAFLD). Patients and Methods : Thirty-four patients with NAFLD, and 19 healthy controls were included. In this study, we measured serum nitrate and advanced oxidation protein product (AOPP) as the oxidizing products and nitrite as the anti-oxidizing marker. Nitrate and nitrite levels were measured using a calorimetric method, and levels of serum AOPP were measured by a spectrophotometric method using a commercial ELISA kit. Results : Serum nitrate and AOPP levels were significantly higher in the NAFLD group compared to the control group. Serum nitrite and N-N levels were similar between the two groups. Serum nitrate and N-N levels were found to be significantly higher in patients with elevated ALT levels compared to patients with normal ALT levels. Serum nitrite and AOPP levels were comparable between these groups. Mean platelet volume (MPV) was significantly lower in the NAFLD group compared to the control group. Conclusions : Serum levels of oxidizing agents including nitrate and AOPP increase in patients with NAFLD. In contrast, serum nitrite, an antioxidant agent, does not adequately increase to compensate for the oxidizing effects in these patients.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage205en_US
dc.identifier.issn0001-5644
dc.identifier.issn1477-4607
dc.identifier.issue2en_US
dc.identifier.pmid26151688
dc.identifier.scopus2-s2.0-84936766624
dc.identifier.scopusqualityQ3
dc.identifier.startpage201en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6180
dc.identifier.volume78en_US
dc.identifier.wosWOS:000361654800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatosteatosisen_US
dc.subjectNAFLDen_US
dc.subjectNitriteen_US
dc.subjectNitrateen_US
dc.subjectAOPPen_US
dc.subjectMPVen_US
dc.subjectALTen_US
dc.titleSerum levels of nitrate, nitrite and advanced oxidation protein products (AOPP) in patients with nonalcoholic fatty liver diseaseen_US
dc.typeArticle

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