What is the impact of intraperitoneal surfactant administration against postoperative intraabdominal adhesion formation? an experimental study

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dc.contributor.authorPala, Şehmus
dc.contributor.authorKuloğlu, Tuncay
dc.contributor.authorAtılgan, Remzi
dc.contributor.authorÖzkan, Zehra Sema
dc.contributor.authorHançer, Serhat
dc.date.accessioned2025-01-21T16:33:45Z
dc.date.available2025-01-21T16:33:45Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/Aim: Surfactant is a surface-active substance that, in addition to its detergent effect, also has effects that reduce inflammation and fibrosis. Because of these effects, it was aimed herein to investigate the effect of intraperitoneal surfactant application on preventing postoperative peritoneal adhesion formation in a uterine horn adhesion model. Materials and methods: Twenty-one Wistar albino rats were randomly divided into 3 groups (G1-G3), as follows: G1 (n = 7): control group. The abdomen was opened and then closed; G2 (n = 7): adhesion group. The abdomen was opened. Then, a 2-cm linear incision was made over the right uterine horn, 2 mL of isotonic saline was administered intraperitoneally, and the abdomen was closed; and G3 (n = 7): treatment group. The abdomen was opened, a 2-cm linear incision was made over the right uterine horn, 2 mL (70 mg/kg) of surfactant was administered intraperitoneally, and the abdomen was closed. After 15 days, the rats were euthanized, the abdomens were reopened, and adhesion scoring was performed. After the right uterine horns were removed and fixed with 10% formalin, appropriate sections were taken from the traumatized tissue, stained with Masson's trichrome, and fibrosis and inflammation scoring were performed. Results: The adhesion area and intensity were significantly higher in G2 than in G1 and G3 (p = 0.001) and were similar in G1 and G3 (p = 0.165). While fibrosis and inflammation were significantly higher in G2 than in G1 and G3 (p = 0.001), there was no difference between G1 and G3 (p = 0.5). Conclusion: Intraperitoneal surfactant administration at a dose of 70 mg/kg was found to be effective in preventing intraabdominal adhesion formation in a rat uterine horn model.
dc.identifier.doi10.55730/1300-0144.5752
dc.identifier.endpage1824
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid38813488
dc.identifier.scopus2-s2.0-85179929417
dc.identifier.scopusqualityQ1
dc.identifier.startpage1817
dc.identifier.trdizinid1221155
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5752
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1221155
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23852
dc.identifier.volume53
dc.identifier.wosWOS:001127245500017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectPostoperative adhesion; uterine horn; rat; surfactant; experimental model
dc.titleWhat is the impact of intraperitoneal surfactant administration against postoperative intraabdominal adhesion formation? an experimental study
dc.typeArticle

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