Potential c-myc Antisense Oligonucleotide Carriers: PCl/PEG/PEI and PLL/PEG/PEI

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dc.contributor.authorDincer, Sevil
dc.contributor.authorTurk, Mustafa
dc.contributor.authorKaragoz, Ayse
dc.contributor.authorUzunalan, Gurhan
dc.date.accessioned2020-06-25T17:51:48Z
dc.date.available2020-06-25T17:51:48Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionDincer, Sevil/0000-0002-6887-6549
dc.description.abstractIn this work, positively charged, micelle-forming polymers were synthesized and used as a model vector to deliver antisense oligodeoxynucleotide (ASODN) into melanoma cells. Polymers and polymer/ASODN complexes were characterized by DLS according to size, charge, and critical micelle concentration. Nanosize and spherical complexes were observed by AFM. Complexes did not reveal significant toxicity to melanoma cells. Antiproliferative effect of the complexes was observed by immunocytochemical staining and estimated as 56.8% with N/P:9. High amount of apoptosis and very small amount of necrosis were estimated. According to the results, these positively charged polymers forming micelle-like structures seem promising as ASODN carriers.en_US
dc.description.sponsorship[TUBITAK-107T864]en_US
dc.description.sponsorshipThis study was supported financially by TUBITAK-107T864. We thank Res. Asist. Yeliz Basaran for AFM images, and Res. Asist. Eray Dalgakiran for DLS analysis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/10731199.2010.506852
dc.identifier.endpage154en_US
dc.identifier.issn1073-1199
dc.identifier.issn1532-4184
dc.identifier.issue3en_US
dc.identifier.pmid20677903
dc.identifier.scopus2-s2.0-79956119109
dc.identifier.scopusqualityN/A
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.3109/10731199.2010.506852
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4992
dc.identifier.volume39en_US
dc.identifier.wosWOS:000290672200006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcareen_US
dc.relation.ispartofArtificial Cells Blood Substitutes And Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantisense oligonucleotideen_US
dc.subjectnon-viral vectorsen_US
dc.subjectc-mycen_US
dc.subjectpoly(lactide)en_US
dc.subjectpoly(caprolactone)en_US
dc.subjectpoly(ethylene glycol)en_US
dc.subjectpolyethylenemineen_US
dc.subjectmicelleen_US
dc.titlePotential c-myc Antisense Oligonucleotide Carriers: PCl/PEG/PEI and PLL/PEG/PEIen_US
dc.typeArticle

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