Tissue responses to novel tissue engineering biodegradable cryogel scaffolds: An animal model

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dc.contributor.authorBolgen, Nimet
dc.contributor.authorVargel, Ibrahim
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorGuzel, Elif
dc.contributor.authorPlieva, Fatima
dc.contributor.authorGalaev, Igor
dc.contributor.authorPiskin, Erhan
dc.date.accessioned2020-06-25T17:48:14Z
dc.date.available2020-06-25T17:48:14Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionBolgen, Nimet/0000-0003-3162-0803; Bolgen, Nimet/0000-0003-3162-0803; Meydanli, E. Elif Guzel/0000-0001-9072-3322; KORKUSUZ, PETEK/0000-0002-7553-3915
dc.description.abstractBiodegradable macroporous cryogels with highly open and interconnected pore structures were produced from dextran modified with oligo L-lactide bearing hydroxyethylmethacrylate (HEMA) end groups in moderately frozen solutions. Tissue responses to these novel scaffolds were evaluated in rats after dorsal subcutaneous implantation, iliac submuscular implantation, auricular implantation, or in calvarial defect model. In no case, either necrosis or foreign body reaction was observed during histological studies. The cryogel scaffolds integrated with the surrounding tissue and the formation of a new tissue were accompanied with significant ingrowth of connective tissue cells and new blood vessels into the cryogel. The tissue responses were significantly lower in auricular and calvarial implantations when compared with the subcutanous and the submuscular implantations. The degradation of the scaffold was slower in bone comparing to soft tissues. The biodegradable cryogels are highly biocompatible and combine extraordinary properties including having soft and elastic nature, open porous structure, and very rapid and controllable swelling. Therefore, the cryogels could be promising candidates for further clinical applications in tissue regeneration. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91 A: 60-68, 2009en_US
dc.description.sponsorshipTurkish Scientific and Technological CouncilTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [105T509]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciencesen_US
dc.description.sponsorshipThis study, which was performed in the contest of EU-FP6-NoE: Expertissues project and Graduate Programme of Hacettepe University (a part of Ph.D. thesis of Miss Nimet Bolgen under the supervision of Prof. Erhan Pisskin), was supported also by Turkish Scientific and Technological Council (Turkish Scientific and Technological Research Council, TUBITAK, Project: Tissuebiomed-105T509). Erhan Pis kin was also supported by Turkish Academy of Sciences (TUBA) as a full member. Nimet Bolgen has received a graduate student-scholarship from TUBITAK.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/jbm.a.32193
dc.identifier.endpage68en_US
dc.identifier.issn1549-3296
dc.identifier.issn1552-4965
dc.identifier.issue1en_US
dc.identifier.pmid18690660
dc.identifier.scopus2-s2.0-70349113963
dc.identifier.scopusqualityQ1
dc.identifier.startpage60en_US
dc.identifier.urihttps://doi.org/10.1002/jbm.a.32193
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4368
dc.identifier.volume91Aen_US
dc.identifier.wosWOS:000269627700007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biomedical Materials Research Part A
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttissue-engineering scaffoldsen_US
dc.subjectcryogelsen_US
dc.subjectbiodegradableen_US
dc.subjectHEMA-L-lactide-dextranen_US
dc.subjectanimal modelen_US
dc.subjecttissue reponsesen_US
dc.titleTissue responses to novel tissue engineering biodegradable cryogel scaffolds: An animal modelen_US
dc.typeArticle

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