The effect of subclinical hypothyroidism on body composition parameters in children

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dc.contributor.authorOdabasi Gunes, Sevinc
dc.contributor.authorTorel Ergur, Ayca
dc.contributor.authorNisanci Kilinc, Fatma
dc.date.accessioned2021-01-14T18:10:34Z
dc.date.available2021-01-14T18:10:34Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractBackground It's known that overt hypothyroidism increases body fat content and weight. There's limited research about the effect of subclinical hypothyroidism (SH) on body composition in children and the effect of LT4 treatment. We aimed to evaluate body composition parameters in healthy subjects and in children with mild SH (MSH) and determine the effect of LT4 treatment. Methods Sixty-four healthy children and 32 children with MSH were included. Anthropometric measurements and hormonal parameters were evaluated. Body composition was evaluated using bioelectric impedance analysis (BIA). Patients were put on LT4 treatment. BIA was performed again after 12 months of therapy. Results There was no significant difference between the anthropometric parameters and basal metabolic rate of the healthy children and the MSH group. The percentage of trunk muscle mass (TMM) in the MSH group was lower than in the control group (P < .05). After 12 months of LT4 treatment, the percentage of total fat-free mass (FFM), TMM and trunk fat-free mass (TFFM) were increased and percentage of total body fat mass and trunk fat mass were decreased (P < .05). The difference between the percentage of TMM in the MSH group and control group was insignificant after LT4 treatment (P > .05). Conclusions The percentage of TMM in children with MSH was found lower than healthy control group. After LT4 treatment, the percentage of the FFM, TMM and TFFM were increased and the difference between percentage of TMM in children with MSH and healthy controls was insignificant. Our data indicated that MSH might be associated with early changes in body composition parameters.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1111/ijcp.13554
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue9en_US
dc.identifier.pmid32460403
dc.identifier.scopus2-s2.0-85085967536
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/ijcp.13554
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12675
dc.identifier.volume74en_US
dc.identifier.wosWOS:000538622200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWILEYen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF CLINICAL PRACTICE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe effect of subclinical hypothyroidism on body composition parameters in childrenen_US
dc.typeArticle

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