Comparison of permissive hypotensive resuscitation, low-volume fluid resuscitation, and aggressive fluid resuscitation therapy approaches in an experimental uncontrolled hemorrhagic shock model

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dc.contributor.authorDurusu, Murat
dc.contributor.authorEryilmaz, Mehmet
dc.contributor.authorOzturk, Gurkan
dc.contributor.authorMentes, Oner
dc.contributor.authorOzer, Tahir
dc.contributor.authorDenir, Turgut
dc.date.accessioned2020-06-25T17:51:15Z
dc.date.available2020-06-25T17:51:15Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description6th Turkish Congress on Trauma and Emergency Surgery -- SEP 04-08, 2007 -- Antalya, TURKEY
dc.descriptionOzturk, Gurkan/0000-0001-8662-636X
dc.description.abstractBACKGROUND In this study, we aimed to compare the efficacy of aggressive fluid resuscitation, low-volume fluid resuscitation and permissive hypotensive resuscitation in an experimental uncontrolled hemorrhagic shock model. METHODS Forty-four male Guinea pigs were used in the study in an experimental uncontrolled shock model. Guinea pigs were split into six groups including normovolemic-normotensive fluid treatment group, normovolemic-permissive hypotensive fluid treatment group, low-volume normotensive fluid treatment group, low-volume permissive hypotensive fluid treatment group, no treatment (n=6), and sham-operated groups (n=6). Resuscitation was initiated when mean arterial pressure (MAP) reached 30 mmHg. In the permissive hypotensive resuscitation group, fluid treatment continued until MAP reached 45 +/- 5 mmHg and in the aggressive fluid groups until MAP reached 60 +/- 5 mmHg. Resuscitation fluid was hetastarch 6% (hydroxyethyl starch) in the low-volume fluid groups and Ringer's lactate in the normovolemic fluid groups. RESULTS Mean survival time was 122.75 +/- 4.83 min in the normovolemic-normotensive fluid group, 130.87 +/- 16.31 min in the normovolemic-permissive hypotensive group, 122.12 +/- 11.53 min in the low-volume-normotensive fluid group, and 152.25 +/- 9.10 min in the low-volume-permissive hypotensive fluid group. Survival time was found significantly higher in the group in which low-volume-permissive hypotensive fluid treatment was applied than in the other groups. CONCLUSION When pressure effect was compared during treatment, permissive-hypotensive resuscitation was found more effective in both groups that received colloid and crystalloid treatment.en_US
dc.identifier.citationDurusu, M., Eryılmaz, M., Öztürk, G., Menteş, Ö., Özer, M. T., Deniz, T. (2010). Comparison of permissive hypotensive resuscitation, low-volume fluid resuscitation, and aggressive fluid resuscitation therapy approaches in an experimental uncontrolled hemorrhagic shock model. Ulusal Travma ve Acil Cerrahi Dergisi, 16(3), 191 - 197.en_US
dc.identifier.endpage197en_US
dc.identifier.issn1306-696X
dc.identifier.issue3en_US
dc.identifier.pmid20517741
dc.identifier.scopus2-s2.0-77954674603
dc.identifier.scopusqualityQ3
dc.identifier.startpage191en_US
dc.identifier.trdizinid106293
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4758
dc.identifier.volume16en_US
dc.identifier.wosWOS:000278128400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGuinea pigsen_US
dc.subjecthemorrhageen_US
dc.subjectresuscitationen_US
dc.subjectshocken_US
dc.titleComparison of permissive hypotensive resuscitation, low-volume fluid resuscitation, and aggressive fluid resuscitation therapy approaches in an experimental uncontrolled hemorrhagic shock modelen_US
dc.typeArticle

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