Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study

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dc.authoridHEPSEN, SEMA/0000-0002-8375-7409
dc.authoridSAYGILI, Emre Sedar/0000-0003-0022-5704
dc.authoridbatman, adnan/0000-0002-0933-6198
dc.authoridMutlu, Ummu/0000-0002-5259-7326
dc.authoridCALAPKULU, MURAT/0000-0002-7445-2275
dc.authoridDemirci, Ibrahim/0000-0003-0498-3115
dc.authoridanil, cuneyd/0000-0003-3802-9733
dc.contributor.authorBatman, Adnan
dc.contributor.authorYazici, Dilek
dc.contributor.authorDikbas, Oguz
dc.contributor.authorAgbaht, Kemal
dc.contributor.authorSaygili, Emre Sedar
dc.contributor.authorDemirci, Ibrahim
dc.contributor.authorBursa, Nurbanu
dc.date.accessioned2025-01-21T16:44:37Z
dc.date.available2025-01-21T16:44:37Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractContext The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism. Methods This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19-related SAT (Cov-SAT), SARS-CoV-2 vaccine-related SAT (Vac-SAT), or control SAT (Cont-SAT) groups. Results Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism. Conclusion Since there is no difference in terms of follow-up parameters and outcomes, COVID-19- and SARS-CoV-2 vaccine-related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism.
dc.identifier.doi10.1210/clinem/dgad235
dc.identifier.endpageE1026
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.issue10
dc.identifier.pmid37186260
dc.identifier.scopus2-s2.0-85171601419
dc.identifier.scopusqualityQ1
dc.identifier.startpageE1013
dc.identifier.urihttps://doi.org/10.1210/clinem/dgad235
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25495
dc.identifier.volume108
dc.identifier.wosWOS:000999236300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEndocrine Soc
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectsubacute thyroiditis; SARS-CoV-2 vaccine; COVID-19
dc.titleSubacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study
dc.typeArticle

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