In vivo performance of simvastatin-loaded electrospun spiral-wound polycaprolactone scaffolds in reconstruction of cranial bone defects in the rat model

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dc.contributor.authorPiskin, Erhan
dc.contributor.authorIsoglu, I. Alper
dc.contributor.authorBolgen, Nimet
dc.contributor.authorVargel, Ibrahim
dc.contributor.authorGriffiths, Sarah
dc.contributor.authorCavusoglu, Tarik
dc.contributor.authorCartmell, Sarah
dc.date.accessioned2020-06-25T17:48:15Z
dc.date.available2020-06-25T17:48:15Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionCartmell, Sarah/0000-0001-6864-0846; Bolgen, Nimet/0000-0003-3162-0803; Bolgen, Nimet/0000-0003-3162-0803; Meydanli, E. Elif Guzel/0000-0001-9072-3322; KORKUSUZ, PETEK/0000-0002-7553-3915
dc.description.abstractReconstruction of large bone defects is still a major problem. Tissue-engineering approaches have become a focus in regeneration of bone. In particular, critical-sized defects do not ossify spontaneously. The use of electrospinning is attracting increasing attention in the preparation of tissue-engineering scaffolds. Recently, acellular scaffolds carrying bioactive agents have been used as scaffolds in "in situ" tissue engineering for soft and hard tissue repair. Poly(epsilon-caprolactone) (PCL) with two different molecular weights were synthesized, and the blends of these two were electrospun into nonwoven membranes composed of nanofibers/micropores. To stimulate bone formation, an active drug, "simvastatin" was loaded either after the membranes were formed or during electrospinning. The matrices were then spiral-wound to produce scaffolds with 3D-structures having both macro- and microchannels. Eight-millimeter diameter critical size cranial defects were created in rats. Scaffolds with or without simvastatin were then implanted into these defects. Samples from the implant sites were removed after 1, 3, and 6 months postimplantation. Bone regeneration and tissue response were followed by X-ray microcomputed tomography and histological analysis. These in vivo results exhibited osseous tissue integration within the implant and mineralized bone restoration of the calvarium. Both microCT and histological data clearly demonstrated that the more successful results were observed with the "simvastatin-containing PCL scaffolds," in which simvastatin was incorporated into the PCL scaffolds during electrospinning. For these samples, bone mineralization was quite significant when compared with the other groups. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 1137-1151, 2009en_US
dc.description.sponsorshipTurkish Scientific and Technological CouncilTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [105T509]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences; BiyomedtekHacettepe Universityen_US
dc.description.sponsorshipContract grant sponsor: Turkish Scientific and Technological Council (Turkish Scientific and Technological Research Council, TUBITAK, Project: Tissuebiomed); contract grant number: 105T509; Contract grant sponsor: Turkish Academy of Sciences (TUBA); Contract grant sponsor: Biyomedteken_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/jbm.a.32157
dc.identifier.endpage1151en_US
dc.identifier.issn1549-3296
dc.identifier.issn1552-4965
dc.identifier.issue4en_US
dc.identifier.pmid18671271
dc.identifier.scopus2-s2.0-68249147417
dc.identifier.scopusqualityQ1
dc.identifier.startpage1137en_US
dc.identifier.urihttps://doi.org/10.1002/jbm.a.32157
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4378
dc.identifier.volume90Aen_US
dc.identifier.wosWOS:000268940100019
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biomedical Materials Research Part A
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbone reconstructionen_US
dc.subjectcranial defectsen_US
dc.subjectanimal modelen_US
dc.subjectbiodegradable scaffoldsen_US
dc.subjectpoly(epsilon-caprolactone)en_US
dc.subjectelectrospinningen_US
dc.subjectspiral-woundingen_US
dc.subjectsimvastatinen_US
dc.titleIn vivo performance of simvastatin-loaded electrospun spiral-wound polycaprolactone scaffolds in reconstruction of cranial bone defects in the rat modelen_US
dc.typeArticle

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