Protective effects of silymarin on fumonisin B-1-induced hepatotoxicity in mice

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dc.contributor.authorSozmen, Mahmut
dc.contributor.authorDevrim, Alparslan Kadir
dc.contributor.authorTunca, Recai
dc.contributor.authorBayezit, Murat
dc.contributor.authorDag, Serpil
dc.contributor.authorEssiz, Dinc
dc.date.accessioned2020-06-25T18:12:17Z
dc.date.available2020-06-25T18:12:17Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionEssiz, Dinc/0000-0002-4759-7858
dc.description.abstractThe present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B-1 (FB1) in BALB/c mice. The mice were divided into six groups (n = 15). Group 1 served as the control. Group 2 was the silymarin control (100 mg/kg by gavage). Groups 3 and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1, intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5 received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), and Group 6 was given a higher dose of FB1 (4.5 mg/kg FB1) with silymarin (100 mg/kg). Silymarin treatment significantly decreased (p < 0.0001) the apoptotic rate. FB1 administration significantly increased (p < 0.0001) proliferating cell nuclear antigen and Ki-67 expression. Furthermore, FB1 elevated the levels of caspase-8 and tumor necrosis factor-alpha mediators while silymarin significantly reduced (p < 0.0001) the expression of these factors. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expressions were significantly elevated in Group 4 (p < 0.0001). Silymarin administration alleviated increased VEGF and FGF-2 expression levels (p < 0.0001). In conclusion, silymarin ameliorated toxic liver damage caused by FB1 in BALB/c mice.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK-TOVAG), TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [106 O 197]en_US
dc.description.sponsorshipThis study was funded by the Scientific and Technological Research Council of Turkey (TUBITAK-TOVAG; Project No. 106 O 197), Turkey. We thank Dr. Ronald Riley (Toxicology and Mycotoxin Research Unit, United States Department of Agriculture-Agricultural Research Service, USA) for generously supplying FB<INF>1</INF>.en_US
dc.identifier.citationSozmen M, Devrim AK, Tunca R, Bayezit M, Dag S, Essiz D. Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice. J Vet Sci. 2014 Mar;15(1):51-60.en_US
dc.identifier.doi10.4142/jvs.2014.15.1.51
dc.identifier.endpage60en_US
dc.identifier.issn1229-845X
dc.identifier.issn1976-555X
dc.identifier.issue1en_US
dc.identifier.pmid24136215
dc.identifier.scopus2-s2.0-84896373652
dc.identifier.scopusqualityQ1
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.4142/jvs.2014.15.1.51
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5850
dc.identifier.volume15en_US
dc.identifier.wosWOS:000333503900006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Soc Veterinary Scienceen_US
dc.relation.ispartofJournal Of Veterinary Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcaspase-8en_US
dc.subjectfumonisin B1en_US
dc.subjectfibroblast growth factor-2en_US
dc.subjectgalectin-3en_US
dc.subjectsilymarinen_US
dc.titleProtective effects of silymarin on fumonisin B-1-induced hepatotoxicity in miceen_US
dc.typeArticle

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