Hepatitis C virus infection prevalence in lichen planus: examination of lesional and normal skin of hepatitis C virus-infected patients with lichen planus for the presence of hepatitis C virus RNA

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dc.contributor.authorErkek, Emel
dc.contributor.authorBozdoğan, Önder
dc.contributor.authorOlut, Ali I.
dc.date.accessioned2020-06-25T17:34:48Z
dc.date.available2020-06-25T17:34:48Z
dc.date.issued2001
dc.departmentKırıkkale Üniversitesi
dc.descriptionOzturk Durmaz, Emel/0000-0003-0661-9720
dc.description.abstractHepatitis C virus (HCV) is the main cause of parenterally transmitted non-A, non-B viral hepatitis. In recent years, a significant association between lichen planus and chronic HCV infection has been reported. Anti-HCV antibody status was evaluated by ELISA in 54 patients with lichen planus and 54 patients with minor dermatological disorders. PCR was used to examine HCV RNA from serum and lesional and nonlesional cutaneous biopsy samples of HCV-infected patients. Seven patients with lichen planus (12.9%) and two patients in the control group (3.7%) were anti-HCV antibody positive. Five out of seven patients with anti-HCV antibodies had demonstrable HCV RNA in lesional skin biopsies. The viral RNA was absent in three out of four patients with lichen planus whose serum samples were positive for HCV RNA and agreed to biopsy of nonlesional skin. The prevalence of HCV infection is not increased in Turkish patients with lichen planus. However our findings suggest that the virus may play a potential pathogenic role by replicating in cutaneous tissue and triggering lichen planus in genetically susceptible HCV-infected patients.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1046/j.1365-2230.2001.00885.x
dc.identifier.endpage544en_US
dc.identifier.issn0307-6938
dc.identifier.issue6en_US
dc.identifier.pmid11678885
dc.identifier.scopus2-s2.0-0034792619
dc.identifier.scopusqualityQ2
dc.identifier.startpage540en_US
dc.identifier.urihttps://doi.org/10.1046/j.1365-2230.2001.00885.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2904
dc.identifier.volume26en_US
dc.identifier.wosWOS:000171586100019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Science Ltden_US
dc.relation.ispartofClinical And Experimental Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleHepatitis C virus infection prevalence in lichen planus: examination of lesional and normal skin of hepatitis C virus-infected patients with lichen planus for the presence of hepatitis C virus RNAen_US
dc.typeArticle

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