Transforming growth factor beta (TGF-beta) levels in otherwise healthy subjects with impaired glucose tolerance

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dc.contributor.authorGenc, Halil
dc.contributor.authorKaradurmus, Nuri
dc.contributor.authorKisa, Ucler
dc.contributor.authorTapan, Serkan
dc.contributor.authorNaharci, Ilkin
dc.contributor.authorSonmez, Alper
dc.contributor.authorDogru, Teoman
dc.date.accessioned2020-06-25T17:51:22Z
dc.date.available2020-06-25T17:51:22Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Naharci, Mehmet/0000-0003-2730-7144; GENC, HALIL/0000-0002-0229-1695; Sonmez, Alper/0000-0002-9309-7715
dc.description.abstractIntroduction: Serum transforming growth factor beta (TGF-beta) level is increased in type-2 diabetes mellitus (T2DM) and certain diabetic complications are mediated by this cytokine. Impaired glucose tolerance (IGT) is a prediabetic condition, and confers a risk for the development of certain diabetes-specific complications. However, no data is available regarding the alteration of TGF-beta in IGT subjects. Therefore, we aimed to investigate TGF-beta levels in otherwise healthy subjects with IGT. Material and methods: Thirty IGT subjects and 30 subjects relatively matched for age, sex and body mass index with normal glucose tolerance were enrolled. Subjects with overt diabetes, cardiovascular, renal or inflammatory disease, or on any medication were excluded. Relevant laboratory examinations were performed by routine methods. Assessment of TGF-beta was made by a commercially available enzyme-linked immunosorbent assay kit. IGT and control subjects were compared for their clinical and laboratory parameters. Results: Serum TGF-beta levels were found to be similar in IGT and normal glucose tolerance subjects (p < 0.05). No statistically significant correlation was found between TGF-beta and other laboratory parameters, either in IGT subjects or in the whole study population. Conclusions: Serum TGF-beta is not elevated in otherwise healthy subjects with IGT. The results of our study imply that the presence of IGT alone is not sufficient to induce TGF-beta elevation; and for the alteration of TGF-beta, worsening of metabolic risk factors may be required. (Pol J Endocrinol 2010; 61 (6): 691-694)en_US
dc.description.sponsorshipGulhane MilitaryMedical Academyen_US
dc.description.sponsorshipThis study is financially supported by grants from Gulhane MilitaryMedical Academy. There is no conflict of interest.en_US
dc.identifier.citationGenc, H., Karadurmus, N., Kisa, U., Tapan, S., Naharci, I., Sonmez, A., & Dogru, T. (2010). Transforming growth factor β (TGF-β) levels in otherwise healthy subjects with impaired glucose tolerance. Endokrynologia Polska, 61(6), 691–694.en_US
dc.identifier.endpage694en_US
dc.identifier.issn0423-104X
dc.identifier.issue6en_US
dc.identifier.pmid21104643
dc.identifier.scopus2-s2.0-78649981239
dc.identifier.scopusqualityQ3
dc.identifier.startpage691en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4827
dc.identifier.volume61en_US
dc.identifier.wosWOS:000208625900008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medicaen_US
dc.relation.ispartofEndokrynologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTGF-betaen_US
dc.subjectimpaired glucose toleranceen_US
dc.subjectcytokineen_US
dc.titleTransforming growth factor beta (TGF-beta) levels in otherwise healthy subjects with impaired glucose toleranceen_US
dc.typeArticle

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