Role of Procalcitonin in Evaluation of the Severity of Acute Cholecystitis

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dc.contributor.authorYuzbasioglu, Yucel
dc.contributor.authorDuymaz, Hikmet
dc.contributor.authorTanrikulu, Ceren Sen
dc.contributor.authorHalhalli, Huseyin Cahit
dc.contributor.authorKoc, Mirac Ozturk
dc.contributor.authorTandogan, Meral
dc.contributor.authorCoskun, Figen
dc.date.accessioned2020-06-25T18:16:08Z
dc.date.available2020-06-25T18:16:08Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionhalhalli, huseyin cahit/0000-0002-0533-5593
dc.description.abstractObjective: The aim of this study is to investigate the relationship between procalcitonin (PCT) level and the severity of acute cholecystitis. Materials and Methods: This study included 200 patients diagnosed with acute cholecystitis. To diagnose and assess the severity of acute cholecystitis; physical examination and abdominal ultrasound findings were evaluated and blood samples were taken to determine white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and levels of coagulation factors, blood gas, C-reactive protein (CRP) and PCT. Patients were classified into three stages, namely, mild, moderate, and severe, according to the severity of acute cholecystitis using the Tokyo guidelines. The role of PCT level in the assessment of severity of acute cholecystitis and the correlation between the stages and PCT level were statistically analyzed. Results: Among patients with acute cholecystitis, 110 (55%) were classified as mild, 61 (30.5%) as moderate, and 29 (14.5%) as severe. Leukocytosis or leukopenia was positive in 48.5%, ESR elevation was found in 72.5%, CRP positivity in 55.5%, PCT elevation in 27%, and positive findings of ultrasonographic imaging in 54.5% of the patients. Serum WBC count, ESR, and CRP and PCT levels increased as the severity of disease increased (p<0.05). PCT could discriminate grade I from grade II-III with 95.45% sensitivity and 46.67% specificity at the best cut-off value of <= 0.52 (p<0.001). PCT could also discriminate grade III from grade I-II with 72.4% sensitivity and 90.06% specificity at the best cut-off value of >0.8 (p< 0.001). Conclusion: PCT level may be considered to be a parameter that could be added to the assessment of the severity of acute cholecystitis in the Tokyo guidelines, although further studies are needed to support our findings.en_US
dc.identifier.citationYüzbaşıoğlu Y., Duymaz H., Tanrıkulu C. Ş., Halhalli H. C., Koc M. O., Tandoğan M., Çoşkun F. (2016). Role of Procalcitonin in Evaluation of the Severity of Acute Cholecystitis. Eurasian Journal of Medicine, 48(3), 162 - 166.en_US
dc.identifier.doi10.5152/eurasianmedj.2016.0052
dc.identifier.endpage166en_US
dc.identifier.issn1308-8734
dc.identifier.issn1308-8742
dc.identifier.issue3en_US
dc.identifier.pmid28149138
dc.identifier.scopus2-s2.0-85010207325
dc.identifier.scopusqualityQ2
dc.identifier.startpage162en_US
dc.identifier.trdizinid215827
dc.identifier.urihttps://doi.org/10.5152/eurasianmedj.2016.0052
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6431
dc.identifier.volume48en_US
dc.identifier.wosWOS:000392738300002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAvesen_US
dc.relation.ispartofEurasian Journal Of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProcalcitoninen_US
dc.subjectacute cholecystitisen_US
dc.subjectseverity of illness indexen_US
dc.titleRole of Procalcitonin in Evaluation of the Severity of Acute Cholecystitisen_US
dc.typeArticle

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