Does serum anti-Mullerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits

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dc.contributor.authorYagci, I. Pir
dc.contributor.authorPekcan, M.
dc.contributor.authorPolat, I. M.
dc.contributor.authorKalender, H.
dc.contributor.authorMacun, H. C.
dc.date.accessioned2020-06-25T18:16:00Z
dc.date.available2020-06-25T18:16:00Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionPEKCAN, MERT/0000-0003-3084-125X
dc.description.abstractAnti-Mullerian hormone (AMH) is produced in the ovary, and thus, it is an excellent marker of follicle pool in females. Current interest is the clinical use of this parameter as a biomarker to assess presence or absence of an intact ovary and to diagnose ovarian remnant syndrome (ORS) following incomplete ovariohysterectomy (OHE) in bitches. The aim of this study was to evaluate serum AMH concentrations in bitches (n = 34) before and after OHE using two different commercial ELISA kits, one of which is based on detecting human AMH and the other is based on detecting human AMH and the other specified for canine AMH. Furthermore, serum AMH levels were also measured in six ORS cases to compare the diagnostic utility of the two different ELISA kits. Serum AMH concentrations measured using the human and canine kit prior to and after OHE were 0.32 +/- 0.24, 0.006 +/- 0.22 ng/ml (p<.001) and 12.08 +/- 22.81, 9.55 +/- 15.42 ng/ml (p=.868), respectively. Thus, the canine-based kit was not able to reveal the significant drop in serum AMH levels. In conclusion, the human-based ELISA kits successfully detected the drop in serum AMH concentrations. Reliable results can only be achieved from well-designed ELISA kits, and AMH levels might be a useful diagnostic tool for the evaluation of presence or absence of ovaries as well as for the detection of ORS cases in bitches.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination UnitKirikkale University [2012/45]en_US
dc.description.sponsorshipThis study was supported by Kirikkale University Scientific Research Projects Coordination Unit (Project number: 2012/45).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/rda.12757
dc.identifier.endpage915en_US
dc.identifier.issn0936-6768
dc.identifier.issn1439-0531
dc.identifier.issue6en_US
dc.identifier.pmid27570051
dc.identifier.scopus2-s2.0-84983489124
dc.identifier.scopusqualityQ2
dc.identifier.startpage910en_US
dc.identifier.urihttps://doi.org/10.1111/rda.12757
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6384
dc.identifier.volume51en_US
dc.identifier.wosWOS:000390030200007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofReproduction In Domestic Animals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDoes serum anti-Mullerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kitsen_US
dc.typeArticle

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