Developmental Differences of the Major Forebrain Commissures in Lissencephalies

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dc.contributor.authorKara, Simay
dc.contributor.authorJissendi-Tchofo, P.
dc.contributor.authorBarkovich, A. J.
dc.date.accessioned2020-06-25T17:49:09Z
dc.date.available2020-06-25T17:49:09Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBACKGROUND AND PURPOSE: Changes of the major forebrain commissures in lissencephaly have not been systematically studied. We investigated the developmental differences of the commissures in patients with varying types of lissencephaly to determine whether specific commissural features may help in distinguishing lissencephaly phenotypes. MATERIALS AND METHODS: MR imaging of 124 patients was retrospectively reviewed. Patients were classified as having cLIS, vLIS, and CBSC, according to cortical phenotype; few patients had genetic diagnoses. Abnormalities of the CC, AC, and HC were recorded, and the overall shape was regarded as hypogenetic, hypoplastic, dysmorphic, a thin flat callosal body with a vertical splenium, and a convex upward callosal body, compared with age-matched controls. Correlations between commissural characteristics and cortical patterns were analyzed by using the Monte Carlo simulation of x(2), extension to m x n table, and Fisher exact tests as appropriate (P < .051. RESULTS: Patients were classified as having cLIS (57.4%), vLIS (38.4%), or CBSC (4.2%). The most common callosal developmental anomaly was hypogenesis with an absent rostrum, a small inferior genu, and a small splenium. An angled (900) splenium was found to be significantly associated with cLIS, as was an excessively convex upward callosal body with VLDLR. ACC with an enlarged AC was found in all cases of ARX. CONCLUSIONS: Specific patterns of the commissure anomalies were associated with certain types of lissencephaly. Callosal anomalies were more common than those of the AC or HC. Developmental variations of commissures may be useful as an imaging criterion in differentiating the groups of lissencephalies and may give insight into the processes causing these malformations.en_US
dc.description.sponsorshipNIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 NS035129]en_US
dc.description.sponsorshipThis work was supported in part by NIH grant R01 NS035129.en_US
dc.identifier.citationKara, S., Jissendi-Tchofo, P., & Barkovich, A. J. (2010). Developmental differences of the major forebrain commissures in lissencephalies. AJNR. American journal of neuroradiology, 31(9), 1602–1607. https://doi.org/10.3174/ajnr.A2133en_US
dc.identifier.doi10.3174/ajnr.A2133
dc.identifier.endpage1607en_US
dc.identifier.issn0195-6108
dc.identifier.issue9en_US
dc.identifier.pmid20522570
dc.identifier.scopus2-s2.0-77958534767
dc.identifier.scopusqualityQ1
dc.identifier.startpage1602en_US
dc.identifier.urihttps://doi.org/10.3174/ajnr.A2133
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4649
dc.identifier.volume31en_US
dc.identifier.wosWOS:000283011300010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Soc Neuroradiologyen_US
dc.relation.ispartofAmerican Journal Of Neuroradiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDevelopmental Differences of the Major Forebrain Commissures in Lissencephaliesen_US
dc.typeArticle

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