Expression of Sigma-Class Glutathione-S-Transferase in Fetal and Pediatric Filum Terminale Samples: A Comparative Study

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dc.contributor.authorKural, Cahit
dc.contributor.authorOgurtuzun, Serpil
dc.contributor.authorSimsek, Gulcin Guler
dc.contributor.authorGuresci, Servet
dc.contributor.authorKaygin, Pinar
dc.contributor.authorYasar, Soner
dc.contributor.authorIzci, Yusuf
dc.date.accessioned2020-06-25T18:34:06Z
dc.date.available2020-06-25T18:34:06Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionSIMSEK, GULCIN/0000-0001-7710-4631
dc.description.abstractBackground and objectives: The pathophysiology of tethered cord syndrome (TCS) in children is not well elucidated. An inelastic filum terminale (FT) is the main factor underlying the stretching of the spinal cord in TCS. Our study aimed to investigate the expression of glutathione-S-transferase (GST) in children and fetal FT samples in order to understand the relationship between this enzyme expression and the development of TCS. Materials and Methods: FT samples were obtained from ten children with TCS (Group 1) and histological and immunohistochemical examinations were performed. For comparison, FT samples from fifteen normal human fetuses (Group 2) were also analyzed using the same techniques. Statistical comparison was made using a Chi-square test. Results: Positive GST-sigma expression was detected in eight (80%) of 10 samples in Group 1. The positive GST-sigma expression was less frequent in nine (60%) of 15 samples from Group 2. No statistically significant difference was detected between the two groups (p = 0.197). Conclusions: Decreased FT elasticity in TCS may be associated with increased GST expression in FT. More prospective studies are needed to clarify the mechanism of the GST-TCS relationship in children.en_US
dc.identifier.citationKural C, Oguztuzun S, Şimşek GG, Guresci S, Kaygın P, Yasar S, Tehli O, Izci Y. Expression of Sigma-Class Glutathione-S-Transferase in Fetal and Pediatric Filum Terminale Samples: A Comparative Study. Medicina. 2019; 55(5):133.en_US
dc.identifier.doi10.3390/medicina55050133
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue5en_US
dc.identifier.pmid31086097
dc.identifier.scopus2-s2.0-85066841549
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina55050133
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7791
dc.identifier.volume55en_US
dc.identifier.wosWOS:000472666200018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttethered cord syndromeen_US
dc.subjectglutathione-S-transferaseen_US
dc.subjectchilden_US
dc.subjectsurgeryen_US
dc.titleExpression of Sigma-Class Glutathione-S-Transferase in Fetal and Pediatric Filum Terminale Samples: A Comparative Studyen_US
dc.typeArticle

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