Associations between human leukocyte antigens and leprosy in the Turkish population

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dc.contributor.authorKoçak, M.
dc.contributor.authorBalci, M.
dc.contributor.authorPence, B.
dc.contributor.authorKundakci, N.
dc.date.accessioned2020-06-25T17:35:03Z
dc.date.available2020-06-25T17:35:03Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractLeprosy is a chronic infection caused by an intracellular microorganism. Genetic predisposition to both disease susceptibility and to host immunological response has been postulated for many years. The aim of this study was to determine whether there is HLA-linked susceptibility to leprosy and its different types. HLA-class I (A, B, C) and II (DR, DQ) antigen frequencies in 80 patients with leprosy (35 borderline lepromatous, 25 lepromatous, 15 borderline tuberculoid, five tuberculoid) were compared with those in 120 healthy individuals. HLA-class I antigens A9, A10, A32, B5, B21, Bw4, Bw6, Cw1, Cw2 and HLA-class II antigens DR9, DR10, DRw52, DQ1, DQ3 were found to be significantly more frequent in patients with leprosy, whereas HLA-class I antigens A3, B44, B49 and HLA-class II antigen DQ5 were so in controls. However, there was no significant difference in HLA-class I and II antigen frequencies between subtypes of leprosy. HLA-A null antigen was found to have weak expression in patients with leprosy. In conclusion, factors other than HLA-class I and class II antigens may have a more critical role in the pathophysiology of leprosy infection in man.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1046/j.1365-2230.2002.01004.x
dc.identifier.endpage239en_US
dc.identifier.issn0307-6938
dc.identifier.issue3en_US
dc.identifier.pmid12072016
dc.identifier.scopus2-s2.0-0036280904
dc.identifier.scopusqualityQ2
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org/10.1046/j.1365-2230.2002.01004.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3006
dc.identifier.volume27en_US
dc.identifier.wosWOS:000176272200017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofClinical And Experimental Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssociations between human leukocyte antigens and leprosy in the Turkish populationen_US
dc.typeArticle

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