Effect of piracetam and nimodipine on full-thickness skin burns in rabbits

Basit Öğe Kaydı
dc.contributor.authorSari, Elif
dc.contributor.authorDincel, Gungor C.
dc.date.accessioned2020-06-25T18:16:24Z
dc.date.available2020-06-25T18:16:24Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionDINCEL, Gungor Cagdas/0000-0002-6985-3197
dc.description.abstractThe potential of several drugs for full-thickness skin burns has been investigated, but the treatment of such burns remains a challenge in plastic surgery. The present study was designed to determine the effect of systemic and topical administration of piracetam and nimodipine on full-thickness skin burn wound healing. A total of 36 New Zealand male rabbits were divided into six groups. Full-thickness skin burns were produced in all the groups, except the control group. Piracetam was administered systemically (piracetam-IV) and topically (piracetam-C) for 14 days, and nimodipine was administered systemically (nimodipine-IV) and topically (nimodipine-C) over the burn wounds for 14 days. The sham group underwent burn injury but was not administered any drug. After 21 days, gross examination and histopathological analysis were performed and the results were compared statistically. Nimodipine-C and nimodipine-IV had no effect on burn wound healing. However, both piracetam-IV and piracetam-C significantly enhanced the healing of the full-thickness skin burn wounds, although the latter was more effective, useful and practical in burn wound healing. The histopathological features of the wounds in the piracetam-C group were closer to those of the control group than those of the other groups. Piracetam-C rather than piracetam-IV may promote full-thickness burn wound healing in rabbits.en_US
dc.identifier.citationSari, E. and Dincel, G.C. (2016), Effect of piracetam and nimodipine on full-thickness skin burns in rabbits. Int Wound J, 13(4): 563-571.en_US
dc.identifier.doi10.1111/iwj.12478
dc.identifier.endpage571en_US
dc.identifier.issn1742-4801
dc.identifier.issn1742-481X
dc.identifier.issue4en_US
dc.identifier.pmid26192365
dc.identifier.scopus2-s2.0-84937501451
dc.identifier.scopusqualityQ1
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.1111/iwj.12478
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6518
dc.identifier.volume13en_US
dc.identifier.wosWOS:000379939600018
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofInternational Wound Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBurnen_US
dc.subjectFull-thickness skin burnen_US
dc.subjectNimodipineen_US
dc.subjectPiracetamen_US
dc.subjectWounden_US
dc.titleEffect of piracetam and nimodipine on full-thickness skin burns in rabbitsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Effect of piracetam and nimodipine on full-thickness skin burns in rabbits.pdf
Boyut:
992 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu