Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in firstdegree relatives of subjects with polycystic ovary syndrome

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dc.contributor.authorYılmaz, Murat
dc.contributor.authorErgün, Mehmet Ali
dc.contributor.authorKarakoç, Ayhan
dc.contributor.authorYurtçu, Erkan
dc.contributor.authorYetkin, İlhan
dc.contributor.authorAyvaz, Göksun
dc.contributor.authorArslan, Metin
dc.date.accessioned2020-06-25T17:40:23Z
dc.date.available2020-06-25T17:40:23Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionergun, mehmet ali/0000-0001-9696-0433
dc.description.abstractAim. This study was designed to examine the relationship between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and insulin resistance (IR) in first-degree relatives of subjects with polycystic ovary syndrome (PCOS). Materials and methods. One hundred and twenty family members of 55 patients with PCOS and 80 unrelated healthy control subjects without a family history of diabetes or PCOS were studied. IR was assessed by homeostatic model assessment (HOMA-IR) and area under the curve (AUC) for insulin during an oral glucose tolerance test in subjects with normal glucose tolerance and controls. Genetic analysis of the PPAR-gamma gene Pro12Ala polymorphism was performed by restriction fragment length polymorphism. Results. Fasting insulin, HONIA-IR and AUC insulin were significantly higher in first-degree relatives of PCOS subjects than in controls. A significantly different allele distribution of the Pro12Ala polymorphism of PPAR-gamma was observed between the two groups, with the frequency of the variant Ala isoform being significantly reduced in the first-degree relatives of PCOS subjects (10.8%, 13 subjects) compared with the control group (22.5%, 18 subjects). All Pro12Ala polymorphisms of the PPAR-gamma gene were heterozygous. Compared with first-degree relatives of PCOS subjects with the Pro12Pro polymorphism of PPAR-gamma, first-degree relatives of PCOS subjects with the Pro12Ala polymorphism had low fasting insulin, HONIA-IR and AUC insulin levels. The combined prevalence rate for impaired glucose tolerance, impaired fasting glucose and diabetes was 40% (16 subjects) in mothers and 52% (20 subjects) in fathers of PCOS women. Conclusion. Our findings suggest that Pro12Ala PPAR-gamma gene polymorphism may be protective against IR and might prevent the development of diabetes mellitus in the first-degree relatives of subjects with PCOS.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/09513590500231593
dc.identifier.endpage210en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue4en_US
dc.identifier.pmid16316841
dc.identifier.scopus2-s2.0-28844489933
dc.identifier.scopusqualityQ2
dc.identifier.startpage206en_US
dc.identifier.urihttps://doi.org/10.1080/09513590500231593
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3416
dc.identifier.volume21en_US
dc.identifier.wosWOS:000234072900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectinsulin resistanceen_US
dc.subjectPro12Ala polymorphismen_US
dc.subjectperoxisome proliferator-activated receptor-gamma geneen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectfamilyen_US
dc.subjectdiabetes mellitusen_US
dc.titlePro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in firstdegree relatives of subjects with polycystic ovary syndromeen_US
dc.typeArticle

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