Association Between Tuberculosis and Atopy: Role of the CD14-159C/T Polymorphism

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dc.contributor.authorKavut, A. Baccioglu
dc.contributor.authorKalpaklioglu, F.
dc.contributor.authorBirben, E.
dc.contributor.authorAyaslioglu, E.
dc.date.accessioned2020-06-25T18:06:49Z
dc.date.available2020-06-25T18:06:49Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The development of allergic hypersensitivity depends on both genetic and environmental factors. Different amounts of microbial products could affect patients with atopy and different genotypes. Objective: We aimed to evaluate the role of varying degrees of exposure to infection by Mycobacterium tuberculosis (tuberculosis) in atopic patients and analyze the association with genetic factors. Methods: We performed CD14-159C/T genotyping in atopic patients (n=118) and healthy individuals (n=62) and recorded the following variables: rural lifestyle, exposure to persons with tuberculosis, bacille Calmette-Guerin (BCG) vaccination, tuberculin skin test (TST), skin prick test, and phenotypes of atopy. Blood samples were analyzed for soluble-CD14 (sCD14), interferon (IFN) gamma, total immunoglobulin (Ig) E, and eosinophil levels. A score was used to identify the likelihood of exposure to tuberculosis. Results: Almost all the study participants had had a BCG vaccination, and half had a positive TST result. No differences were observed between atopic patients with high/low tuberculosis scores and CD14 genotypes in terms of atopic phenotypes, allergen sensitization, and levels of total IgE, sCD14, and IFN-gamma. However, the frequency of asthma was higher in atopic patients with a high tuberculosis score and was not associated with CD14 genotypes. Eosinophil counts in blood were higher in atopic patients with a high tuberculosis score and CC+CT genotypes. Conclusions: These results suggest that the C allele of the CD14-159C/T polymorphism has a marked effect on eosinophil levels in atopic patients with increased exposure to tuberculosis. In addition, the degree of exposure to tuberculosis in atopic patients may modify the development of asthma.en_US
dc.description.sponsorshipKirikkale UniversityKirikkale University [2008/5]en_US
dc.description.sponsorshipThis work was supported by a grant from Kirikkale University Projects of Scientific Research (Grant No. 2008/5) awarded to Drs Baccioglu Kavut, Kalpaklioglu, and Ayaslioglu. None of the authors have any other financial disclosures to make.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage207en_US
dc.identifier.issn1018-9068
dc.identifier.issue3en_US
dc.identifier.pmid22697010
dc.identifier.scopus2-s2.0-84860855537
dc.identifier.scopusqualityQ2
dc.identifier.startpage201en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5365
dc.identifier.volume22en_US
dc.identifier.wosWOS:000305365200007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEsmon Publicidad S Aen_US
dc.relation.ispartofJournal Of Investigational Allergology And Clinical Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtopyen_US
dc.subjectBCGen_US
dc.subjectCD14 polymorphismen_US
dc.subjectRural lifeen_US
dc.subjectTuberculosisen_US
dc.titleAssociation Between Tuberculosis and Atopy: Role of the CD14-159C/T Polymorphismen_US
dc.typeArticle

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