Evaluation of Dimethyl Sulfoxide and Dexamethasone on Pulmonary Contusion in Experimental Blunt Thoracic Trauma
dc.contributor.author | Boybeyi, Ozlem | |
dc.contributor.author | Bakar, Bulent | |
dc.contributor.author | Aslan, Mustafa Kemal | |
dc.contributor.author | Atasoy, Pinar | |
dc.contributor.author | Kisa, Ucler | |
dc.contributor.author | Soyer, Tutku | |
dc.date.accessioned | 2020-06-25T18:07:58Z | |
dc.date.available | 2020-06-25T18:07:58Z | |
dc.date.issued | 2014 | |
dc.department | Kırıkkale Üniversitesi | |
dc.description | KISA, Ucler/0000-0002-8131-6810; Soyer, Tutku/0000-0003-1505-6042 | |
dc.description.abstract | Background A thoracic traumamodel was designed to evaluate the effect of dimethyl sulfoxide (DMSO) and dexamethasone (DX) on histopathologic and oxidative changes in lung parenchyma seen after pulmonary contusion. Methods Twenty-four Wistar albino rats were included in the study. They were allocated into control (CG, n = 6), sham (SG, n = 6), DX (DXG, n = 6), and DMSO (DMG, n = 6) groups. Only a lung biopsy was performed in CG. In the experimental groups, blunt thoracic trauma was induced by dropping a cylindrical metal weight (0.5 kg) through a stainless steel tube onto the right hemithorax from a height of 0.4 m (E = 1.96 J). In the SG, 1 mL of physiologic saline was injected intraperitoneally, in the DXG 10 mg/kg of DX was injected intraperitoneally, and in the DMG 1.2 g/mL of DMSO was injected intraperitoneally 15 minutes after trauma. After 6 hours, lung biopsy was performed for histopathologic and oxidative injury markers. Results Histopathologically, congestion, hemorrhage, neutrophil infiltration, endothelial-nitric oxide synthase (E-NoS), and total pathologic score were significantly higher in SG, DXG, and DMG when compared with CG (p < 0.05). Neutrophil infiltration, total pathologic score, and E-NoS were significantly decreased in DMG when compared with SG and DXG (p < 0.05). Biochemically, superoxide dismutase (SOD) level was significantly higher in SG, DXG, and DMG than in CG. SOD level was significantly lower in DXG and DMG than in SG (p < 0.05). Conclusion DMSO prevents further injury by decreasing neutrophil infiltration and endothelial injury in lung contusions. DX may have a role in the progression of inflammation but not in preventing the pathologic disruption of pulmonary parenchyma. | en_US |
dc.description.sponsorship | Kirikkale University Scientific Research CouncilKirikkale University [2012/87] | en_US |
dc.description.sponsorship | The study was supported by Kirikkale University Scientific Research Council (2012/87). There is no financial or personal relationship with other people or organizations that could inappropriately influence (bias) the work. There is no conflict of interest. | en_US |
dc.identifier.citation | closedAccess | en_US |
dc.identifier.doi | 10.1055/s-0033-1352591 | |
dc.identifier.endpage | 715 | en_US |
dc.identifier.issn | 0171-6425 | |
dc.identifier.issn | 1439-1902 | |
dc.identifier.issue | 8 | en_US |
dc.identifier.pmid | 23939657 | |
dc.identifier.startpage | 710 | en_US |
dc.identifier.uri | https://doi.org/10.1055/s-0033-1352591 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/5701 | |
dc.identifier.volume | 62 | en_US |
dc.identifier.wos | WOS:000346338600013 | |
dc.identifier.wosquality | Q3 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | |
dc.publisher | Georg Thieme Verlag Kg | en_US |
dc.relation.ispartof | Thoracic And Cardiovascular Surgeon | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | dimethyl sulfoxide | en_US |
dc.subject | dexamethasone | en_US |
dc.subject | experimental | en_US |
dc.subject | chest | en_US |
dc.subject | lung | en_US |
dc.subject | trauma | en_US |
dc.title | Evaluation of Dimethyl Sulfoxide and Dexamethasone on Pulmonary Contusion in Experimental Blunt Thoracic Trauma | en_US |
dc.type | Article |