Evaluation of Dimethyl Sulfoxide and Dexamethasone on Pulmonary Contusion in Experimental Blunt Thoracic Trauma

dc.contributor.authorBoybeyi, Ozlem
dc.contributor.authorBakar, Bulent
dc.contributor.authorAslan, Mustafa Kemal
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorKisa, Ucler
dc.contributor.authorSoyer, Tutku
dc.date.accessioned2020-06-25T18:07:58Z
dc.date.available2020-06-25T18:07:58Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Soyer, Tutku/0000-0003-1505-6042
dc.description.abstractBackground A thoracic traumamodel was designed to evaluate the effect of dimethyl sulfoxide (DMSO) and dexamethasone (DX) on histopathologic and oxidative changes in lung parenchyma seen after pulmonary contusion. Methods Twenty-four Wistar albino rats were included in the study. They were allocated into control (CG, n = 6), sham (SG, n = 6), DX (DXG, n = 6), and DMSO (DMG, n = 6) groups. Only a lung biopsy was performed in CG. In the experimental groups, blunt thoracic trauma was induced by dropping a cylindrical metal weight (0.5 kg) through a stainless steel tube onto the right hemithorax from a height of 0.4 m (E = 1.96 J). In the SG, 1 mL of physiologic saline was injected intraperitoneally, in the DXG 10 mg/kg of DX was injected intraperitoneally, and in the DMG 1.2 g/mL of DMSO was injected intraperitoneally 15 minutes after trauma. After 6 hours, lung biopsy was performed for histopathologic and oxidative injury markers. Results Histopathologically, congestion, hemorrhage, neutrophil infiltration, endothelial-nitric oxide synthase (E-NoS), and total pathologic score were significantly higher in SG, DXG, and DMG when compared with CG (p < 0.05). Neutrophil infiltration, total pathologic score, and E-NoS were significantly decreased in DMG when compared with SG and DXG (p < 0.05). Biochemically, superoxide dismutase (SOD) level was significantly higher in SG, DXG, and DMG than in CG. SOD level was significantly lower in DXG and DMG than in SG (p < 0.05). Conclusion DMSO prevents further injury by decreasing neutrophil infiltration and endothelial injury in lung contusions. DX may have a role in the progression of inflammation but not in preventing the pathologic disruption of pulmonary parenchyma.en_US
dc.description.sponsorshipKirikkale University Scientific Research CouncilKirikkale University [2012/87]en_US
dc.description.sponsorshipThe study was supported by Kirikkale University Scientific Research Council (2012/87). There is no financial or personal relationship with other people or organizations that could inappropriately influence (bias) the work. There is no conflict of interest.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/s-0033-1352591
dc.identifier.endpage715en_US
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue8en_US
dc.identifier.pmid23939657
dc.identifier.startpage710en_US
dc.identifier.urihttps://doi.org/10.1055/s-0033-1352591
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5701
dc.identifier.volume62en_US
dc.identifier.wosWOS:000346338600013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic And Cardiovascular Surgeon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdimethyl sulfoxideen_US
dc.subjectdexamethasoneen_US
dc.subjectexperimentalen_US
dc.subjectchesten_US
dc.subjectlungen_US
dc.subjecttraumaen_US
dc.titleEvaluation of Dimethyl Sulfoxide and Dexamethasone on Pulmonary Contusion in Experimental Blunt Thoracic Traumaen_US
dc.typeArticle

Dosyalar