Levels of lipoprotein and homocysteine in non-obese and obese patients with polylcystic ovary syndrome

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dc.contributor.authorYılmaz, Murat
dc.contributor.authorBiri, Aydan
dc.contributor.authorBukan, Neslihan
dc.contributor.authorKarakoç, Ayhan
dc.contributor.authorSancak, Banu
dc.contributor.authorToruner, Füsun
dc.contributor.authorPaşaoğlu, Hatice
dc.date.accessioned2020-06-25T17:40:39Z
dc.date.available2020-06-25T17:40:39Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim. This study was designed to examine the relationship between homocysteine (Hcy), lipoprotein levels and insulin resistance in obese and non-obese patients with polycystic ovary syndrome (PCOS). Materials and methods. Eighty-five patients (38 obese, 47 non-obese) with PCOS and 50 healthy subjects (25 obese, 25 nonobese) were included in the study. PCOS was defined according to the Homburg criterion. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-S), insulin, 17-hydroxyprogesterone, free testosterone, androstenedione, vitamin B-12 and folate were measured. Also, serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), lipoprotein (a) (Lp(a)), apoprotein B (Apo B) and apoprotein A (Apo A) were determined. Plasma Hey levels were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA). Results. Plasma Hey levels were significantly higher in women with PCOS than in healthy women. HOMA-R (insulin resistance) was significantly higher in women with PCOS compared with healthy women. Serum fasting TC, LDL-C, TG, Apo B, vitamin B-12 and folate levels were similar between PCOS and control groups. Lp(a) levels were higher in PCOS patients than in control subjects, whereas HDL-C and Apo A levels were lower. Compared with obese PCOS subjects, nonobese PCOS subjects had low HOMA-R, TC, LDL-C, TG, Apo B, Lp(a) and androgen levels. Plasma Hey levels, serum HDL-C and Apo A levels were similar between obese and non-obese women with PCOS. Levels of HDL-C and Apo A were lower in both obese and non-obese PCOS patients than in obese and non-obese control subjects, whereas Lp(a) levels were higher. No correlation was observed between Plasma Hey, body mass index, HOMA-R, serum androgen levels, TC, LDL-C, HDL-C, Apo A, Apo B and Lp(a) levels. Conclusion. These results showed that elevated insulin resistance and plasma Hey levels, and changes in serum lipid profile, which are possible risk factors for cardiovascular disorders, play important roles in the development of cardiovascular disease in both obese and non-obese patients with PCOS.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/09513590400027265
dc.identifier.endpage263en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue5en_US
dc.identifier.pmid16019370
dc.identifier.scopus2-s2.0-21244477051
dc.identifier.scopusqualityQ2
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.1080/09513590400027265
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3512
dc.identifier.volume20en_US
dc.identifier.wosWOS:000230206400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjecthomocysteineen_US
dc.subjectinsulin resistanceen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectlipoproteinen_US
dc.titleLevels of lipoprotein and homocysteine in non-obese and obese patients with polylcystic ovary syndromeen_US
dc.typeArticle

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