Expressions of CYP and GST Isoenzymes in Human Gastric Tumor and Non-Tumor Tissues

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dc.contributor.authorSimsek, Gulcin G.
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorBozer, Busra
dc.contributor.authorKilic, Murat
dc.contributor.authorKocdogan, Arzu K.
dc.contributor.authorKaygin, Pinar
dc.contributor.authorBulus, Hakan
dc.date.accessioned2020-06-25T18:30:07Z
dc.date.available2020-06-25T18:30:07Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionKilic, Murat/0000-0002-1377-2021
dc.description.abstractIn this study we investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1 and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 isoenzymes in gastric tumor and surrounding tumor free (normal) gastric tissues from 40 patients. For immunohistochemical studies, tissues were obtained from 40 patients with gastric adenocarcinoma. Tumor and non-tumoral control tissues of patients were compared according to their staining intensity. Relationships between CYP and GST isoenzyme expressions in adenocarcinoma tissues were examined by the Mann Whitney-U test, and the clinicopathological data were examined by the Spearman's Rank Correlation test. CYP1B1, GSTT1, GSTO1 and GSTK1 expressions in gastric cancer cells were significantly higher than those in gastric normal epithelial cells (p < 0.05). However, CYP1A1, CYP2E1 and GSTP1 expressions were not significantly higher in tumor epithelium than those in normal epithelium in human gastric adenocancer (p < 0.05). Among the studied CYPs and GSTs, there was not statistically significant association between the studied isoenzyme expressions and age, gender and tumor grade ( p > 0.05). In patients with gastric adenocarcinoma, CYP1B1, GSTO1, GSTT1, and GSTK1 protein expressions are higher in tumor than normal gastric tissues.en_US
dc.identifier.citationŞimşek G. G., Oğuztüzün S., Bozer B., Kılıç M., Koçdoğan A. K., Kaygın P., Gürbüz N., Buluş H. (2018). Expressions of CYP and GST Isoenzymes in Human Gastric Tumor and Non-Tumor Tissues. Uluslararası Hematoloji-Onkoloji Dergisi, 28(1), 36 - 44.en_US
dc.identifier.doi10.4999/uhod.182016
dc.identifier.endpage44en_US
dc.identifier.issn1306-133X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85045202077
dc.identifier.scopusqualityQ4
dc.identifier.startpage36en_US
dc.identifier.trdizinid272398
dc.identifier.urihttps://doi.org/10.4999/uhod.182016
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7565
dc.identifier.volume28en_US
dc.identifier.wosWOS:000429216000005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastric adenocarcinomaen_US
dc.subjectCytochrome P450 enzymesen_US
dc.subjectGlutathione-S-transferaseen_US
dc.titleExpressions of CYP and GST Isoenzymes in Human Gastric Tumor and Non-Tumor Tissuesen_US
dc.typeArticle

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