Effect of synbiotics in the treatment of smokers and non-smokers with gingivitis: randomized controlled trial

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dc.contributor.authorErcan, N.
dc.contributor.authorOlgun, E.
dc.contributor.authorKisa, U.
dc.contributor.authorYalim, M.
dc.date.accessioned2021-01-14T18:10:42Z
dc.date.available2021-01-14T18:10:42Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractBackground To evaluate the efficacy of synbiotic tablets on the clinical and biochemical parameters of smokers and non-smokers with gingivitis. Methods Eighty patients with gingivitis [40 smokers (+), 40 non-smokers (-)] were randomly assigned to test (T) or control (C) groups. Four groups were defined: T(+), T(-), C(+) and C(-). The subjects daily chewed a synbiotic or placebo tablet for 30 days. The gingival crevicular fluid levels of interleukin (IL)-6, IL-8 and IL-10 were determined as the primary outcome variables. Results The clinical and biochemical parameters for all groups significantly reduced compared with the baseline (P < 0.05). While there were no significant differences between the groups for gingival index, the plaque index was significantly higher in both smoker groups than that in the T(-) group during the second month (P < 0.05). IL-8 levels in C(-) and IL-6 levels in both control groups were significantly higher than those in the T(+) group. The IL-10 levels in both control groups were significantly higher than those in the T(-) group during the second month (P < 0.05). Conclusions Adjunctive synbiotic tablets significantly reduce subclinical therapeutic outcomes for both smokers and non-smokers compared with placebo according to the biochemical parameters.en_US
dc.description.sponsorshipScientific Research Project Fund of Kirikkale UniversityKirikkale University [2014/01]en_US
dc.description.sponsorshipThe authors thank Cell Biotech (Gyeonggi-do, South Korea) for providing the synbiotic and placebo tablets used. This study was funded by the Scientific Research Project Fund of Kirikkale University under the project number 2014/01.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1111/adj.12755
dc.identifier.endpage219en_US
dc.identifier.issn0045-0421
dc.identifier.issn1834-7819
dc.identifier.issue3en_US
dc.identifier.pmid32147827
dc.identifier.scopus2-s2.0-85082751773
dc.identifier.scopusqualityQ2
dc.identifier.startpage210en_US
dc.identifier.urihttps://doi.org/10.1111/adj.12755
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12740
dc.identifier.volume65en_US
dc.identifier.wosWOS:000522739600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWILEYen_US
dc.relation.ispartofAUSTRALIAN DENTAL JOURNAL
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGingival crevicular fluiden_US
dc.subjectgingivitisen_US
dc.subjectperiodontal medicineen_US
dc.subjectprobioticsen_US
dc.subjectsmokingen_US
dc.titleEffect of synbiotics in the treatment of smokers and non-smokers with gingivitis: randomized controlled trialen_US
dc.typeArticle

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