Evaluation of hormone replacement therapy which may have an adrenomedullin-mediated protective effect on cardiovascular disorders

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dc.contributor.authorBayram, Merih
dc.contributor.authorBayram, Orhan
dc.contributor.authorBilgili, M. Yasemin Karadeniz
dc.contributor.authorÇaglayan, Osman
dc.contributor.authorIlhan, Mustafa N.
dc.date.accessioned2020-06-25T17:43:45Z
dc.date.available2020-06-25T17:43:45Z
dc.date.issued2007
dc.description.abstractBackground and aims: This study aimed to determine whether there is an adrenomedullin (AM)-mediated protective effect of postmenopausal estroger/progestin therapy (HRT) against cardiovascular disorders. Methods: A total of 22 post-menopausal women without hysterectomy undergoing postmenopausal symptoms (aged 43-52) were treated with conjugated equine estrogen (0.625 mg/die) plus medroxyprogesterone acetate (2.5 mg/die) for six months. The flow velocity of the right middle cerebral artery [measured as resistance index (RI) and pulsatility index (PI)], plasma levels of adrenomedullin and endothelin-1 (ET-1), mean baseline ratio of AM to ET-1, and lipid profiles were assessed before and after HRT. Results: A statistically significant difference was found for triglycerides, total cholesterol, AM/ET-1 ratio and right middle cerebral artery PI (p < 0.05), without any significant differences in HDL, LDL, AM, ET-1, systolic blood pressure, diastolic blood pressure, a right middle cerebral artery RI (p > 0.05) between pre- and post-HRT. Conclusions: Adrenomedullin may be added to other vasoactive peptides as a new potential candidate for HRT-mediated vascular protection. The ratio of AM/ET-1 vs AM or ET-1 alone may be a useful biological marker of this protection.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage227en_US
dc.identifier.issn1594-0667
dc.identifier.issn1720-8319
dc.identifier.issue3en_US
dc.identifier.pmid17607091
dc.identifier.scopus2-s2.0-34447259111
dc.identifier.scopusqualityQ1
dc.identifier.startpage224en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3880
dc.identifier.volume19en_US
dc.identifier.wosWOS:000249820100010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofAging Clinical And Experimental Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectendothelin-1en_US
dc.subjectHRTen_US
dc.subjectmenopauseen_US
dc.subjectmiddle cerebral artery PI and RIen_US
dc.titleEvaluation of hormone replacement therapy which may have an adrenomedullin-mediated protective effect on cardiovascular disordersen_US
dc.typeArticle

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