Impact of Vascularization Type on Peripheral Nerve Microstructure

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dc.contributor.authorVargel, İbrahim
dc.date.accessioned2020-06-25T17:48:27Z
dc.date.available2020-06-25T17:48:27Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractExperimental and clinical studies have demonstrated that vascularized nerve grafts are superior to nonvascularized nerve grafts with respect to healing. By means of the inherent vascularity in vascularized nerve grafts, Schwann cells remain viable, and endoneurial necrosis and fibrosis are not seen. In this study the effects of three different vascularization patterns oil the vascular microstructure of a nerve segment in the rat based on the femoral artery and vein was investigated. Sixty adult male Wistar Albino rats were divided into five groups. In each group, a 1.5-cm segment of femoral nerve was transected at two sides, without disturbing the unity of the contents of the femoral sheath. The experimental design consisted of prefabricated venous nerve segment, venous nerve segment, arterial nerve segment, no blood flow, and controls groups. To assess the microstructure of the nerve segment, myelin and Schwann cell morphology and fibrosis were examined. There were many Schwann cells with near normal morphology in the venous nerve segment and arterial nerve segment groups. In conclusion, the venous nerve segment model in which Schwann cell viability was high due to the presence of sufficient and uninterrupted blood supply to the nerve graft, resulting in successful nerve healing, showed superior results over others.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/s-0028-1104557
dc.identifier.endpage253en_US
dc.identifier.issn0743-684X
dc.identifier.issue4en_US
dc.identifier.pmid19085817
dc.identifier.scopus2-s2.0-67649210460
dc.identifier.scopusqualityQ1
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1055/s-0028-1104557
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4456
dc.identifier.volume25en_US
dc.identifier.wosWOS:000265871700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofJournal Of Reconstructive Microsurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFemoral nerve microstructureen_US
dc.subjectperipheral nerve reconstructionen_US
dc.subjectvenous nerve graften_US
dc.titleImpact of Vascularization Type on Peripheral Nerve Microstructureen_US
dc.typeArticle

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