Assessment of Pulmonary Arterial Hypertension and Vascular Resistance by Measurements of the Pulmonary Arterial Flow Velocity Curve in the Absence of a Measurable Tricuspid Regurgitant Velocity in Childhood Congenital Heart Disease

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dc.contributor.authorÇevik, Ayhan
dc.contributor.authorKula, Serdar
dc.contributor.authorOlguntürk, Rana
dc.contributor.authorTunaoğlu, F. Sedef
dc.contributor.authorOğuz, A. Deniz
dc.contributor.authorSaylan, Berna
dc.contributor.authorŞanlı, Cihat
dc.date.accessioned2020-06-25T18:07:27Z
dc.date.available2020-06-25T18:07:27Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptioncevik, berna saylan/0000-0002-5384-4982; Cilsal, Erman/0000-0001-8485-0376
dc.description.abstractThis study aimed to determine mean pulmonary arterial pressure (PAPmean) and pulmonary vascular resistance (PVR) using transthoracic echocardiography (TTE) measurements of the pulmonary artery flow velocity curve in children with pulmonary arterial hypertension (PAH) and congenital heart disease when the tricuspid regurgitant velocity (TRV) is not sufficient. This study enrolled 29 congenital heart disease cases with pulmonary arterial hypertension and 40 healthy subjects followed at our center. The mean age was 66.9 +/- A 77.9 months in the patient group and 76.3 +/- A 62.1 months in the control group. A positive correlation was found between TRV and systolic pulmonary arterial pressure (r = 0.394, p = 0.035, 95 % confidence interval [CI] = 0.032-0.665), whereas a negative correlation was found between corrected acceleration time (AcTc) and PAPmean (r = -0.559, p = 0.002, 95 % CI = -0.768 to -0.242). Furthermore, a negative correlation was found between parameters TRV and AcTc (r = -0.383, p = 0.001, 95 % CI = -0.657 to -0.019). Based on the cutoff criterion of 124 ms for AcTc, sensitivity was found to be 79.3 % and specificity to be 77.5 % in distinguishing between the PAH patients and the healthy control patients (receiver operating characteristic [ROC] area under the curve [AUC] = 0.804, 95 % CI = 0.691-0.890, p < 0.0001). The sensitivity and specificity of the concomitant use of AcTc and/or TRV were found to be 90 and 73 %, respectively, in distinguishing between the PAH patients and the the healthy control patients. The data obtained by TTE also can be appropriate for measuring PAPmean, PVR, and the vasoreactivity test and for determining the priority of implementing cardiac catheterization even if there is no measurable TRV value.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00246-012-0520-4
dc.identifier.endpage655en_US
dc.identifier.issn0172-0643
dc.identifier.issn1432-1971
dc.identifier.issue3en_US
dc.identifier.pmid23052666
dc.identifier.scopus2-s2.0-84879505343
dc.identifier.scopusqualityQ2
dc.identifier.startpage646en_US
dc.identifier.urihttps://doi.org/10.1007/s00246-012-0520-4
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5581
dc.identifier.volume34en_US
dc.identifier.wosWOS:000315567200024
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCongenital heart diseaseen_US
dc.subjectEchocardiographyen_US
dc.subjectPulmonary hypertensionen_US
dc.subjectPulmonary vascular resistanceen_US
dc.titleAssessment of Pulmonary Arterial Hypertension and Vascular Resistance by Measurements of the Pulmonary Arterial Flow Velocity Curve in the Absence of a Measurable Tricuspid Regurgitant Velocity in Childhood Congenital Heart Diseaseen_US
dc.typeArticle

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