Effects of granulocyte-colony stimulating factor on peritoneal defense mechanisms and bacterial translocation after administration of systemic chemotherapy in rats

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dc.contributor.authorÇerçi, Celal
dc.contributor.authorErgin, Çagrı
dc.contributor.authorEroğlu, Erol
dc.contributor.authorAğalar, Canan
dc.contributor.authorAğalar, Fatih
dc.contributor.authorÇerçi, Sureyya
dc.contributor.authorBülbül, Mahmut
dc.date.accessioned2020-06-25T17:43:47Z
dc.date.available2020-06-25T17:43:47Z
dc.date.issued2007
dc.descriptionErgin, Cagri/0000-0001-7783-8723
dc.description.abstractAIM: To investigate the effects of granulocyte-colony stimulating factor (G-CSF) on peritoneal defense mechanisms and bacterial translocation after systemic 5-Fluorouracil (5-FU) administration. METHODS: Thirty Wistar albino rats were divided into three groups; the control, 5-FU and 5-FU + G-CSF groups. We measured bactericidal activity of the peritoneal fluid, phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid, total peritoneal cell counts and cell types of peritoneal washing fluid. Bacterial translocation was quantified by mesenteric lymph node, liver and spleen tissue cultures. RESULTS: Systemic 5-FU reduced total peritoneal cell counts, neutrophils and macrophage numbers. It also altered bactericidal activity of the peritoneal fluid and phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid. 5-FU also caused significant increase in frequencies of bacterial translocation at the liver and mesenteric lymph nodes. G-CSF decreased bacterial translocation, it significantly enhanced bactericidal activity of the peritoneal fluid and phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid. It also increased total peritoneal cell counts, neutrophils and macrophage numbers. CONCLUSION: Systemic 5-FU administration caused bacterial translocation, decreased the bactericidal activity of peritoneal fluid and phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid. G-CSF increased both bactericidal activity of the peritoneal fluid and phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid, and prevented the bacterial translocation. We conclude that intraperitoneal GCSF administration protects the effects of systemic 5-FU on peritoneal defense mechanisms. (C) 2007 The WJG Press. All rights reserved.en_US
dc.identifier.citationCerci, C., Ergin, C., Eroglu, E., Agalar, C., Agalar, F., Cerci, S., & Bulbul, M. (2007). Effects of granulocyte-colony stimulating factor on peritoneal defense mechanisms and bacterial translocation after administration of systemic chemotherapy in rats. World journal of gastroenterology, 13(18), 2596–2599. https://doi.org/10.3748/wjg.v13.i18.2596en_US
dc.identifier.doi10.3748/wjg.v13.i18.2596
dc.identifier.endpage2599en_US
dc.identifier.issn1007-9327
dc.identifier.issn2219-2840
dc.identifier.issue18en_US
dc.identifier.pmid17552008
dc.identifier.scopus2-s2.0-34250689551
dc.identifier.scopusqualityQ1
dc.identifier.startpage2596en_US
dc.identifier.urihttps://doi.org10.3748/wjg.v13.i18.2596
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3899
dc.identifier.volume13en_US
dc.identifier.wosWOS:000247024700011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal Of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgranulocyte-colony stimulating factoren_US
dc.subject5-fluorouracilen_US
dc.subjectbacterial translocationen_US
dc.subjectperitoneal defense mechanismsen_US
dc.titleEffects of granulocyte-colony stimulating factor on peritoneal defense mechanisms and bacterial translocation after administration of systemic chemotherapy in ratsen_US
dc.typeArticle

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