The relationship between the serotonin 2A receptor gene-1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patients

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dc.contributor.authorOz, Merve Demirbugen
dc.contributor.authorUckun, Zuhal
dc.contributor.authorYuce-Artun, Nazan
dc.contributor.authorBaskak, Bora
dc.contributor.authorOzdemir, Hatice
dc.contributor.authorOzel, Tugba Kizil
dc.contributor.authorSuzen, H. Sinan
dc.date.accessioned2020-06-25T18:29:27Z
dc.date.available2020-06-25T18:29:27Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionoz, Merve Demirbugen/0000-0002-8484-1207; ozguven, halise/0000-0002-9355-2757; Suzen, Sinan/0000-0003-1779-5850
dc.description.abstractObjective: The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder. Methods: A total of 128 patients were enrolled, 63 patients received CIT, whereas 65 patients were treated with SERT. Nausea/vomiting were assessed with the UKU Side-effects Rating Scale at baseline and at the end of the second and fourth weeks. Polymerase chain reaction-restriction fragment length polymorphism technique was employed to determine genetic differences. Results: We have found that, in the patients treated with CIT, there was a nominally significant difference in the genotypic distribution associated with -1438A/G polymorphism between patients with and without nausea (X-2 = 6.15, p = 0.041). Moreover, logistic regression analysis revealed a significant association between nausea/vomiting as a side effect and -1438A/G polymorphism. That is, patients with the G allele were at a higher risk for developing nausea/vomiting (p = 0.044, odds ratio = 2.213). The 102T/C polymorphism in the HTR2A gene had no significant effect on the nausea/vomiting as a side effect among participants treated with either CIT or SERT. Conclusion: The present study suggests the association of the HTR2A gene -1438A/G polymorphism with nausea/vomiting as a side effect related to CIT treatment.en_US
dc.description.sponsorshipCoordinatorship of Scientific Research Projects of Ankara University [17H0237003]; Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109S147]en_US
dc.description.sponsorshipThe Coordinatorship of Scientific Research Projects of Ankara University, Grant/Award Number: 17H0237003; The Scientific and Technological Research Council of Turkey (TUBITAK), Grant/Award Number: 109S147en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/hup.2673
dc.identifier.issn0885-6222
dc.identifier.issn1099-1077
dc.identifier.issue5en_US
dc.identifier.pmid30221791
dc.identifier.scopus2-s2.0-85053519959
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/hup.2673
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7320
dc.identifier.volume33en_US
dc.identifier.wosWOS:000446988100003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofHuman Psychopharmacology-Clinical And Experimental
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcitalopramen_US
dc.subjectnauseaen_US
dc.subjectpolymorphismen_US
dc.subjectserotonin-2A receptoren_US
dc.subjectsertralineen_US
dc.titleThe relationship between the serotonin 2A receptor gene-1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patientsen_US
dc.typeArticle

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