Expression of CYP and GST in human normal and colon tumor tissues

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dc.contributor.authorBulus, H.
dc.contributor.authorOguztuzun, S.
dc.contributor.authorSimsek, G. Guler
dc.contributor.authorKilic, M.
dc.contributor.authorAda, A. Oguz
dc.contributor.authorGol, S.
dc.contributor.authorIscan, M.
dc.date.accessioned2020-06-25T18:34:23Z
dc.date.available2020-06-25T18:34:23Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionKilic, Murat/0000-0002-1377-2021; Oguztuzun, Serpil/0000-0002-5892-3735; Bozer, Busra/0000-0002-7280-4417; kaya kocdogan, arzu/0000-0002-3689-3061; Ada, Ahmet Oguz/0000-0001-9987-0572
dc.description.abstractWe investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1, and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 in colon tumor and surrounding normal colon tissues. Tissues were obtained from 47 patients with colon adenocarcinoma and the staining intensity of tumor and control tissues was compared. CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTT1, GSTO1 and GSTK1 expressions in colon cancer cells were significantly greater than those in normal colon epithelial cells. No significant relation was found between the isoenzyme expressions and age, gender, smoking status, tumor grade and tumor stage. The higher expressions of CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTO1, GSTT1 and GSTK1 in tumor than in normal colon tissues may be important for colon cancer progression and development.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/10520295.2018.1493220
dc.identifier.endpage9en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid30092668
dc.identifier.scopus2-s2.0-85051954497
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1493220
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7887
dc.identifier.volume94en_US
dc.identifier.wosWOS:000458977400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenocarcinomaen_US
dc.subjectcolonen_US
dc.subjectcytochrome P450en_US
dc.subjectglutathione-S-transferaseen_US
dc.subjecthumanen_US
dc.subjectsmoking statusen_US
dc.titleExpression of CYP and GST in human normal and colon tumor tissuesen_US
dc.typeArticle

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