Novel amoxicillin nanoparticles formulated as sustained release delivery system for poultry use

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dc.contributor.authorGuncum, E.
dc.contributor.authorBakirel, T.
dc.contributor.authorAnlas, C.
dc.contributor.authorEkici, H.
dc.contributor.authorIsiklan, N.
dc.date.accessioned2020-06-25T18:29:30Z
dc.date.available2020-06-25T18:29:30Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionBakirel, Tulay/0000-0001-5805-2178;
dc.description.abstractAmoxicillin is used in the treatment and prevention of a wide range of diseases in poultry breeding. However, its short half-life and low bioavailability restrict its clinical application in these species. Entrapment of drugs into polymeric nanoparticles (nps) presents a means to improve gastrointestinal absorption and oral bioavailability of drugs. This study was aimed to overcome limitation of amoxicillin use in poultry breeding. Amoxicillin was loaded into sodium alginate-polyvinyl alcohol (NaAlg-PVA) blend nps, and characterization of the prepared nps was performed. For pharmacokinetic study, commercial male broilers were used and comparative pharmacokinetics of free and nanoparticle form of amoxicillin were investigated. Twenty-one broilers were divided into three groups. All groups received 10mg/kg drug. Blood samples were collected, and drug plasma concentrations were determined by HPLC. The results demonstrated that the particle size, zeta potential, encapsulation efficiency, and loading capacity of the nps were 513.96 +/- 19.46nm, -45.36 +/- 1.35mV, 43.66 +/- 3.30, and 12.06 +/- 0.83%, respectively. In vitro drug release exhibited a biphasic pattern with an initial burst release of 18% within 2hr followed by a sustained release over 22hr. The pharmacokinetic results showed that amoxicillin nps have higher bioavailability and longer plasma half-life (p<.01) than free amoxicillin. These results indicate that amoxicillin nano formulation is suitable for oral administration in broilers.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [44188]en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University, Grant/Award Number: 44188en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/jvp.12505
dc.identifier.endpage598en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue4en_US
dc.identifier.pmid29604071
dc.identifier.scopus2-s2.0-85044778088
dc.identifier.scopusqualityQ1
dc.identifier.startpage588en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.12505
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7344
dc.identifier.volume41en_US
dc.identifier.wosWOS:000437133600013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Veterinary Pharmacology And Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamoxicillinen_US
dc.subjectbroileren_US
dc.subjectnanoparticlesen_US
dc.subjectpharmacokineticsen_US
dc.subjectsodium alginateen_US
dc.titleNovel amoxicillin nanoparticles formulated as sustained release delivery system for poultry useen_US
dc.typeArticle

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