Oxidative and histopathological effects of the application of electrosurgical devices to the penile tissue of rats

Basit Öğe Kaydı
dc.contributor.authorGünal, Yasemin Dere
dc.contributor.authorBoybeyi, Özlem
dc.contributor.authorAtasoy, Pınar
dc.contributor.authorKısa, Üçler
dc.contributor.authorAslan, Mustafa Kemal
dc.contributor.authorBakar, Bülent
dc.contributor.authorSoyer, Tutku
dc.date.accessioned2021-01-14T18:10:52Z
dc.date.available2021-01-14T18:10:52Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionSoyer, Tutku/0000-0003-1505-6042
dc.description.abstractIntroduction This study was performed to evaluate the oxidative and histopathological changes that occur following the application of electrosurgical devices (monopolar or bipolar cautery) to penile tissue. Material and methods Eighteen Wistar albino male rats were randomly distributed into three groups. In the control group (CG, n = 6), all penile tissues were sampled without any additional process following the administration of anesthesia. In the monopolar cautery group (MPG, n = 6), a 15-W cauterization process lasting 5 s was performed on an approximately 2 mm(2) area of the ventral side of the penile shaft, 0.5 cm proximal to the edge of the glans in the midline. Bipolar cautery was practiced in the third group (BPG, n = 6) using the same techniques outlined in the previous statement. Penile tissues consisted of the cautery application area, the edge of the glans, and dorsal side of the penis and were sampled after 90 min; then, histopathological evaluation and biochemical examination involving malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) measurements were performed. Results and discussion Histopathologically, the MPG and BPG demonstrated increased inflammation, fibrosis, and epithelial loss in the urethra in the areas to which cautery was applied as compared to the CG (P < 0.05). The vascular structures of the corpus cavernosa were significantly decreased in the cautery application area of both the MPG and the BPG as compared to the CG (P < 0.05). In the Masson's trichrome stained samples, significant collagen deposition was observed in the cautery application area both in the MPG and the BPG as compared to the CG (P < 0.05). However, S-100 staining was decreased in these groups as compared to the CG (P < 0.05). S-100 staining was also decreased in the MPG as compared to the BPG on the edge of the glans (P < 0.05). Biochemically, MDA values were significantly increased in the MPG as compared to the CG and the BPG (P < 0.05). Conclusion Monopolar and bipolar cautery both did cause oxidative changes and triggered inflammatory, vascular, and peripheral nerve alterations in the cautery application area while bipolar cautery did not cause any distant effects.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jpurol.2019.10.005
dc.identifier.issn1477-5131
dc.identifier.issn1873-4898
dc.identifier.issue1en_US
dc.identifier.pmid31787583
dc.identifier.scopus2-s2.0-85075833703
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jpurol.2019.10.005
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12805
dc.identifier.volume16en_US
dc.identifier.wosWOS:000538165900015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC UROLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCircumcisionen_US
dc.subjectHypospadiasen_US
dc.subjectElectrosurgical deviceen_US
dc.subjectOxidative stressen_US
dc.subjectPenile tissueen_US
dc.titleOxidative and histopathological effects of the application of electrosurgical devices to the penile tissue of ratsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Oxidative and histopathological effects of the application of electrosurgical devices to the penile tissue of rats.pdf
Boyut:
1.13 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Daha fazla yükle