The effects of cyclopentolate on intraocular pressure and retrobulbar hemodynamics in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma

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dc.contributor.authorTaner, P
dc.contributor.authorUnal, B
dc.contributor.authorDemirbas, E
dc.contributor.authorErgin, A
dc.date.accessioned2020-06-25T17:40:04Z
dc.date.available2020-06-25T17:40:04Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPURPOSE. To evaluate the changes of intraocular pressure (IOP) and retrobulbar hemodynamics after cyclopentolate administration in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. METHODS. Eighteen patients with pseudoexfoliation syndrome and 18 patients with pseudoexfoliation glaucoma were enrolled in the study. After baseline measurements of IOP, the peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) of the ophthalmic, central retinal, and posterior ciliary arteries were investigated by color Doppler imaging. Then, 1% cyclopentolate was instilled in one eye of each subject. After 45 minutes of instillation of the cyclopentolate, the measurements of IOP and retrobulbar blood flow velocities were repeated. The results were compared with those of 20 age-matched normal subjects. RESULTS. Neither IOP nor retrobulbar blood flow velocities changed significantly in control subjects after cyclopentolate administration. IOP increased significantly after cyclopentolate instillation in pseudo exfoliation syndrome (p=0.004). Retrobulbar blood velocities did not change significantly after the cyclopentolate in this group. In pseudoexfoliation glaucoma group, it was observed that basal mean IOP showed a statistically significant increase after cyclopentolate drop (p=0.002). Although blood flow velocities of ophthalmic artery did not change significantly, PSV and EDV of the central retinal and posterior ciliary arteries decreased significantly (p<0.05) and RI of the posterior ciliary artery increased significantly (p=0.01) after cyclopentolate instillation. CONCLUSIONS. On the basis of our findings, pseudoexfoliation appears to be a predictive factor for an IOP rise after cyclopentolate. In pseudoexfoliation glaucoma patients, an increase of IOP after cyclopentolate could lead to a decreased retrobulbar blood flow. IOP must be rechecked after cyclopentolate administration in these patients to avoid further damage to the ganglion cells.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage400en_US
dc.identifier.issn1120-6721
dc.identifier.issue5en_US
dc.identifier.pmid15506601
dc.identifier.scopus2-s2.0-8344283530
dc.identifier.scopusqualityQ2
dc.identifier.startpage394en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3240
dc.identifier.volume14en_US
dc.identifier.wosWOS:000224450600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWichtig Editoreen_US
dc.relation.ispartofEuropean Journal Of Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPseudoexfoliation syndromeen_US
dc.subjectPseudoexfoliation glaucomaen_US
dc.subjectcyclopentolateen_US
dc.subjectcolor Doppler imagingen_US
dc.titleThe effects of cyclopentolate on intraocular pressure and retrobulbar hemodynamics in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucomaen_US
dc.typeArticle

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