Effect of Initial Periodontal Therapy on Oxidative Stress Markers in Gingival Crevicular Fluid, Saliva, and Serum in Smokers and Non-Smokers With Chronic Periodontitis

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dc.contributor.authorHendek, Meltem Karsiyaka
dc.contributor.authorErdemir, Ebru Olgun
dc.contributor.authorKisa, Ucler
dc.contributor.authorOzcan, Gonen
dc.date.accessioned2020-06-25T18:15:43Z
dc.date.available2020-06-25T18:15:43Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810;
dc.description.abstractBackground: The aim of this case-control study with an intervention arm is to determine the effect of initial periodontal treatment on oxidative stress biomarkers in smokers and non-smokers with chronic periodontitis (CP). Methods: The study included 47 patients with CP (24 smokers [S+ P+] and 23 non-smokers [S-P+]) and 46 periodontally healthy individuals (23 smokers [S+ P-] and 23 non-smokers [S-P-]) for a total of 93 participants. Gingival crevicular fluid (GCF), serum, and saliva samples were obtained and clinical periodontal measurements were recorded at baseline and at the first and third months after periodontal therapy. 8-hydroxydeoxyguanosine (OHdG) and 4-hydroxynonenal (HNE) and enzyme activity of glutathione peroxidase (GSH-Px) were analyzed with enzyme-linked immunosorbent assay. Results: The level of 8-OHdD in GCF was found to be significantly higher in both periodontitis groups compared with both periodontally healthy groups. 8-OHdG and GSH-Px in saliva in both periodontitis groups were significantly increased compared with the S-P-group. In the S+ P+ group, 4-HNE in GCF was found to be significantly higher than in periodontally healthy participants. After initial periodontal treatment, the levels of 8-OHdG in GCF and saliva were significantly decreased in both periodontitis groups. Conclusion: Initial periodontal therapy may be helpful for diminishing oxidative stress in periodontitis.en_US
dc.description.sponsorshipScientific Research Project Fund of Kirikkale UniversityKirikkale University [2012/97]en_US
dc.description.sponsorshipThis research was supported by the Scientific Research Project Fund of Kirikkale University under the project number 2012/97. The authors express their thanks to assistant professors Mesut Akyol and Pervin Demir in the Department of Biostatistics and Medical Informatics, University of Yildirim Beyazit, Turkey, for providing statistics support. The authors report no conflicts of interest related to this study.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1902/jop.2014.140338
dc.identifier.endpage282en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue2en_US
dc.identifier.pmid25325515
dc.identifier.scopus2-s2.0-84925013408
dc.identifier.scopusqualityQ1
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2014.140338
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6235
dc.identifier.volume86en_US
dc.identifier.wosWOS:000349380500013
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Periodontology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAldehydesen_US
dc.subjectdeoxyguanosineen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectoxidative stressen_US
dc.subjectperiodontitisen_US
dc.subjectsmokingen_US
dc.titleEffect of Initial Periodontal Therapy on Oxidative Stress Markers in Gingival Crevicular Fluid, Saliva, and Serum in Smokers and Non-Smokers With Chronic Periodontitisen_US
dc.typeArticle

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